[HTML][HTML] Spatial transcriptomics: recent developments and insights in respiratory research
WJ Wang, LX Chu, LY He, MJ Zhang, KT Dang… - Military Medical …, 2023 - Springer
The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …
Spatially resolved transcriptomics technology facilitates cancer research
Q Wang, Y Zhi, M Zi, Y Mo, Y Wang, Q Liao… - Advanced …, 2023 - Wiley Online Library
Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor
occurrence and development for its ability to study gene expression at the individual cell …
occurrence and development for its ability to study gene expression at the individual cell …
[HTML][HTML] Pathomic features reveal immune and molecular evolution from lung preneoplasia to invasive adenocarcinoma
Recent statistics on lung cancer, including the steady decline of advanced diseases and the
dramatically increasing detection of early-stage diseases and indeterminate pulmonary …
dramatically increasing detection of early-stage diseases and indeterminate pulmonary …
[HTML][HTML] Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma
Y Haga, Y Sakamoto, K Kajiya, H Kawai, M Oka… - Nature …, 2023 - nature.com
The mechanism underlying the development of tumors, particularly at early stages, still
remains mostly elusive. Here, we report whole-genome long and short read sequencing …
remains mostly elusive. Here, we report whole-genome long and short read sequencing …
Machine learning-based integration develops a macrophage-related index for predicting prognosis and immunotherapy response in lung adenocarcinoma
Z Li, M Guo, W Lin, P Huang - Archives of Medical Research, 2023 - Elsevier
Background Macrophages play a critical role in tumor immune microenvironment (TIME)
formation and cancer progression in lung adenocarcinoma (LUAD). However, few studies …
formation and cancer progression in lung adenocarcinoma (LUAD). However, few studies …
Combining single-cell RNA sequencing data and transcriptomic data to unravel potential mechanisms and signature genes of the progression of idiopathic pulmonary …
X Zhou, F Tan, S Zhang, T Zhang - Functional & Integrative Genomics, 2023 - Springer
Patients with idiopathic pulmonary fibrosis (IPF) have a significantly higher prevalence of
lung adenocarcinoma (LUAD) than normal subjects, although the underlying association is …
lung adenocarcinoma (LUAD) than normal subjects, although the underlying association is …
Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single‐Cell …
X Zhang, B Liang, Y Huang, H Meng, Z Li… - Advanced …, 2023 - Wiley Online Library
The increased use of low‐dose computed tomography screening has led to more frequent
detection of early stage lung tumors, including minimally invasive adenocarcinoma (MIA). To …
detection of early stage lung tumors, including minimally invasive adenocarcinoma (MIA). To …
[HTML][HTML] Combined Inhibition of UBE2C and PLK1 Reduce Cell Proliferation and Arrest Cell Cycle by Affecting ACLY in Pan-Cancer
K Liang, Q Wang, L Qiu, X Gong, Z Chen… - International Journal of …, 2023 - mdpi.com
Various studies have shown that the cell-cycle-related regulatory proteins UBE2C, PLK1,
and BIRC5 promote cell proliferation and migration in different types of cancer. However …
and BIRC5 promote cell proliferation and migration in different types of cancer. However …
The seductive allure of spatial biology: accelerating new discoveries in the life sciences
A Kulasinghe, F Wood, G Belz - Immunology and Cell Biology, 2023 - Wiley Online Library
Spatial biology is a rapidly developing field which enables the visualization of protein and
transcriptomic data while preserving tissue context and architecture. Initially used in …
transcriptomic data while preserving tissue context and architecture. Initially used in …
[HTML][HTML] Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencing
Q Xue, W Peng, S Zhang, X Wei, L Ye, Z Wang… - Frontiers in …, 2023 - frontiersin.org
Immunotherapy has made great strides in the treatment of lung cancer, but a significant
proportion of patients still do not respond to treatment. Therefore, the identification of novel …
proportion of patients still do not respond to treatment. Therefore, the identification of novel …