[HTML][HTML] Spatial transcriptomics: recent developments and insights in respiratory research

WJ Wang, LX Chu, LY He, MJ Zhang, KT Dang… - Military Medical …, 2023 - Springer
The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …

Spatially resolved transcriptomics technology facilitates cancer research

Q Wang, Y Zhi, M Zi, Y Mo, Y Wang, Q Liao… - Advanced …, 2023 - Wiley Online Library
Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor
occurrence and development for its ability to study gene expression at the individual cell …

[HTML][HTML] Pathomic features reveal immune and molecular evolution from lung preneoplasia to invasive adenocarcinoma

P Chen, FR Rojas, X Hu, A Serrano, B Zhu, H Chen… - Modern Pathology, 2023 - Elsevier
Recent statistics on lung cancer, including the steady decline of advanced diseases and the
dramatically increasing detection of early-stage diseases and indeterminate pulmonary …

[HTML][HTML] Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma

Y Haga, Y Sakamoto, K Kajiya, H Kawai, M Oka… - Nature …, 2023 - nature.com
The mechanism underlying the development of tumors, particularly at early stages, still
remains mostly elusive. Here, we report whole-genome long and short read sequencing …

Machine learning-based integration develops a macrophage-related index for predicting prognosis and immunotherapy response in lung adenocarcinoma

Z Li, M Guo, W Lin, P Huang - Archives of Medical Research, 2023 - Elsevier
Background Macrophages play a critical role in tumor immune microenvironment (TIME)
formation and cancer progression in lung adenocarcinoma (LUAD). However, few studies …

Combining single-cell RNA sequencing data and transcriptomic data to unravel potential mechanisms and signature genes of the progression of idiopathic pulmonary …

X Zhou, F Tan, S Zhang, T Zhang - Functional & Integrative Genomics, 2023 - Springer
Patients with idiopathic pulmonary fibrosis (IPF) have a significantly higher prevalence of
lung adenocarcinoma (LUAD) than normal subjects, although the underlying association is …

Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single‐Cell …

X Zhang, B Liang, Y Huang, H Meng, Z Li… - Advanced …, 2023 - Wiley Online Library
The increased use of low‐dose computed tomography screening has led to more frequent
detection of early stage lung tumors, including minimally invasive adenocarcinoma (MIA). To …

[HTML][HTML] Combined Inhibition of UBE2C and PLK1 Reduce Cell Proliferation and Arrest Cell Cycle by Affecting ACLY in Pan-Cancer

K Liang, Q Wang, L Qiu, X Gong, Z Chen… - International Journal of …, 2023 - mdpi.com
Various studies have shown that the cell-cycle-related regulatory proteins UBE2C, PLK1,
and BIRC5 promote cell proliferation and migration in different types of cancer. However …

The seductive allure of spatial biology: accelerating new discoveries in the life sciences

A Kulasinghe, F Wood, G Belz - Immunology and Cell Biology, 2023 - Wiley Online Library
Spatial biology is a rapidly developing field which enables the visualization of protein and
transcriptomic data while preserving tissue context and architecture. Initially used in …

[HTML][HTML] Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencing

Q Xue, W Peng, S Zhang, X Wei, L Ye, Z Wang… - Frontiers in …, 2023 - frontiersin.org
Immunotherapy has made great strides in the treatment of lung cancer, but a significant
proportion of patients still do not respond to treatment. Therefore, the identification of novel …