Single-pill fixed-dose drug combinations to reduce blood pressure: the right pill for the right patient

R Sarzani, G Laureti, A Gezzi… - … in Chronic Disease, 2022 - journals.sagepub.com
Arterial hypertension is one of the major causes of cardiovascular morbidity and mortality
worldwide. Effective and sustained reduction in blood pressure is essential to reduce …

[PDF][PDF] Polypill in cardiovascular disease prevention: recent advances.

A Coca, JM Castellano, M Camafort, V Fuster - 2023 - core.ac.uk
Triple therapy with lipid‑lowering, antihypertensive, and antiplatelet agents reduces the risk
of recur‑rent cardiovascular fatal and nonfatal events, cardiovascular mortality, and total …

The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease–expert …

L Grigorian-Shamagian, A Coca, J Morais… - BMC proceedings, 2023 - Springer
Although the cardiovascular (CV) polypill concept is not new and several guidelines state
that a CV polypill should be considered an integral part of a comprehensive CV disease …

Starting antihypertensive drug treatment with combination therapy: controversies in hypertension-pro side of the argument

A Persu, M Lopez-Sublet, EAEH Algharably… - Hypertension, 2021 - Am Heart Assoc
Οne of the highlights of the current recommendations of the European Society of Cardiology
(ESC) and the European Society of Hypertension (ESH) for the management of arterial …

Is chymase 1 a therapeutic target in cardiovascular disease?

CM Ferrario, S Ahmad, R Speth… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Non-angiotensin converting enzyme mechanisms of angiotensin II production
remain underappreciated in part due to the success of current therapies to ameliorate the …

Practical decision algorithms for the use of the cardiovascular polypill in secondary prevention in Europe

L Grigorian-Shamagian, K Edel… - Frontiers in …, 2021 - frontiersin.org
The main objective of cardiovascular disease (CVD) prevention is to reduce morbidity and
mortality. Despite recommendations on evidence-based pharmacological treatment and …

The Polypill: A New Alternative in the Prevention and Treatment of Cardiovascular Disease

EVP Espinosa, EM Matute, DM Sosa Guzmán… - Journal of Clinical …, 2024 - mdpi.com
Cardiovascular disease (CVD) is the primary cause of death and disability worldwide.
Although age-standardized CVD mortality rates decreased globally by 14.5% between 2006 …

Recommendations for the care of patients with cardiovascular disease in health emergency situations: a call to action

C Suárez Fernández, P Armario… - Current Medical …, 2023 - Taylor & Francis
COVID-19 has had a negative impact on the health care of patients with cardiovascular
disease and patients at high risk of cardiovascular disease. The restrictions affecting access …

The CNIC-polypill (acetylsalicylic acid, atorvastatin, and ramipril), an effective and cost-saving secondary prevention strategy compared with other therapeutic options …

R Dalmau, A Cordero, L Masana, E Ruiz… - … Heart Journal Open, 2024 - academic.oup.com
Aims The retrospective NEPTUNO study evaluated the effectiveness of the Centro Nacional
de Investigaciones Cardiovasculares (CNIC)-polypill (including acetylsalicylic acid, ramipril …

Single-pill combination for treatment of hypertension: Just a matter of practicality or is there a real clinical benefit?

A Coca, SP Whelton, M Camafort… - European Journal of …, 2024 - Elsevier
Elevated blood pressure (BP) is the largest contributor to the incident cardiovascular
disease worldwide. Despite explicit guideline recommendations for the diagnosis and …