Next-generation sequencing technology: current trends and advancements

H Satam, K Joshi, U Mangrolia, S Waghoo, G Zaidi… - Biology, 2023 - mdpi.com
Simple Summary Next-generation sequencing (NGS) is a powerful tool used in genomics
research. NGS can sequence millions of DNA fragments at once, providing detailed …

Next-Generation sequencing transforming clinical practice and precision medicine

D Yadav, B Patil-Takbhate, A Khandagale… - Clinica Chimica …, 2023 - Elsevier
Next-generation sequencing (NGS) has revolutionized the field of genomics and is rapidly
transforming clinical diagnosis and precision medicine. This advanced sequencing …

Single-cell analysis of the epitranscriptome: RNA modifications under the microscope

E Crespo-García, A Bueno-Costa, M Esteller - RNA biology, 2024 - Taylor & Francis
The identification of mechanisms capable of modifying genetic information by the addition of
covalent RNA modifications distinguishes a level of complexity in gene expression which …

Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma

C Zhang, J Xiao, L Fa, F Jiang, H Jiang, L Zhou… - BMC …, 2023 - Springer
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however,
elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to …

Transcriptomic analysis of Vibrio alginolyticus challenged by Rhizoma coptidis reveals mechanisms of virulence genes

Z Zhu, XJ Xu, J Huang, G Xu, SC Liu, F Hong, Y Chen… - Gene, 2024 - Elsevier
Rhizoma coptidis, a Chinese herbal medicine widely used to treat various bacterial
infections, has the potential to develop antibiotic substitutes to overcome the drug resistance …

[HTML][HTML] The Role of Biomarkers in HPV-Positive Head and Neck Squamous Cell Carcinoma: Towards Precision Medicine

A Krsek, L Baticic, V Sotosek, T Braut - Diagnostics, 2024 - ncbi.nlm.nih.gov
Head and neck cancer (HNC) represents a significant global health challenge, with
squamous cell carcinomas (SCCs) accounting for approximately 90% of all HNC cases …

Exposure to Mycotoxin Citrinin Promotes Carcinogenic Potential of Human Renal Cells

JF Tsai, TS Wu, YT Huang, WJ Lin… - Journal of Agricultural …, 2023 - ACS Publications
Mycotoxin citrinin (CTN), commonly found in food and health supplements, may induce
chromosomal instability. In this study, human renal proximal tubule epithelial cells …

Comparative case study on NAMs: towards enhancing specific target organ toxicity analysis

K Jochum, A Miccoli, C Sommersdorf, O Poetz… - Archives of …, 2024 - Springer
Traditional risk assessment methodologies in toxicology have relied upon animal testing,
despite concerns regarding interspecies consistency, reproducibility, costs, and ethics. New …

reanalyzerGSE: tackling the everlasting lack of reproducibility and reanalyses in transcriptomics

JL Ruiz, LC Terrón-Camero, J Castillo-González… - bioRxiv, 2023 - biorxiv.org
In the current context of transcriptomics democratization, there is an unprecedented surge in
the number of studies and datasets. However, advances are hampered by aspects such as …

Transcriptome Analysis of Compensatory Growth and Meat Quality Alteration after Varied Restricted Feeding Conditions in Beef Cattle

T Deng, M Liang, L Du, K Li, J Li, L Qian, Q Xue… - International Journal of …, 2024 - mdpi.com
Compensatory growth (CG) is a physiological response that accelerates growth following a
period of nutrient limitation, with the potential to improve growth efficiency and meat quality …