[HTML][HTML] Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
Pathophysiology of sleep apnea
JA Dempsey, SC Veasey, BJ Morgan… - Physiological …, 2010 - journals.physiology.org
Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or
reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence …
reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence …
Adult obstructive sleep apnea: pathophysiology and diagnosis
SP Patil, H Schneider, AR Schwartz, PL Smith - Chest, 2007 - Elsevier
Obstructive sleep apnea (OSA) is a highly prevalent disease characterized by recurrent
episodes of upper airway obstruction that result in recurrent arousals and episodic …
episodes of upper airway obstruction that result in recurrent arousals and episodic …
A randomized controlled clinical trial exploring safety and tolerability of sulthiame in sleep apnea
J Hedner, K Stenlöf, D Zou, E Hoff… - American journal of …, 2022 - atsjournals.org
Rationale: Current therapies for obstructive sleep apnea (OSA) are limited by insufficient
efficacy, compliance, or tolerability. An effective pharmacological treatment for OSA is …
efficacy, compliance, or tolerability. An effective pharmacological treatment for OSA is …
[HTML][HTML] Central chemoreceptors: locations and functions
E Nattie, A Li - Comprehensive physiology, 2012 - ncbi.nlm.nih.gov
Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …
Central sleep apnea
S Javaheri, JA Dempsey - Comprehensive Physiology, 2013 - Wiley Online Library
Neurophysiologically, central apnea is due to a temporary failure in the pontomedullary
pacemaker generating breathing rhythm. As a polysomnographic finding, central apneas …
pacemaker generating breathing rhythm. As a polysomnographic finding, central apneas …
Crossing the apnoeic threshold: causes and consequences
JA Dempsey - Experimental physiology, 2005 - Wiley Online Library
This brief review addresses the characteristics, lability and the mechanisms underlying the
hypocapnic‐induced apnoeic threshold which is unmasked during NREM sleep. The role of …
hypocapnic‐induced apnoeic threshold which is unmasked during NREM sleep. The role of …
[HTML][HTML] Targeting endotypic traits with medications for the pharmacological treatment of obstructive sleep apnea. A review of the current literature
L Taranto-Montemurro, L Messineo… - Journal of clinical …, 2019 - mdpi.com
Obstructive sleep apnea (OSA) is a highly prevalent condition with few therapeutic options.
To date there is no approved pharmacotherapy for this disorder, but several attempts have …
To date there is no approved pharmacotherapy for this disorder, but several attempts have …
Obstructive sleep apnea and kidney disease: a potential bidirectional relationship?
Chronic kidney disease (CKD) is associated with high mortality rates and heavy economic
and social burdens. Nearly 10% of the United States population suffer from CKD, with fatal …
and social burdens. Nearly 10% of the United States population suffer from CKD, with fatal …
Increased propensity for central apnea in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure
A Salloum, JA Rowley, JH Mateika… - American journal of …, 2010 - atsjournals.org
Rationale: There is increasing evidence of increased ventilatory instability in patients with
obstructive sleep apnea (OSA), but previous investigations have not studied whether the …
obstructive sleep apnea (OSA), but previous investigations have not studied whether the …