Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or
reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence …

Obstructive sleep apnea (OSA) is a highly prevalent disease characterized by recurrent
episodes of upper airway obstruction that result in recurrent arousals and episodic …

Rationale: Current therapies for obstructive sleep apnea (OSA) are limited by insufficient
efficacy, compliance, or tolerability. An effective pharmacological treatment for OSA is …

Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …

Neurophysiologically, central apnea is due to a temporary failure in the pontomedullary
pacemaker generating breathing rhythm. As a polysomnographic finding, central apneas …

This brief review addresses the characteristics, lability and the mechanisms underlying the
hypocapnic‐induced apnoeic threshold which is unmasked during NREM sleep. The role of …

Obstructive sleep apnea (OSA) is a highly prevalent condition with few therapeutic options.
To date there is no approved pharmacotherapy for this disorder, but several attempts have …

Chronic kidney disease (CKD) is associated with high mortality rates and heavy economic
and social burdens. Nearly 10% of the United States population suffer from CKD, with fatal …

Rationale: There is increasing evidence of increased ventilatory instability in patients with
obstructive sleep apnea (OSA), but previous investigations have not studied whether the …