The ability of neurons to regenerate an axon after injury is determined by both the
surrounding environment and factors intrinsic to the damaged neuron. We have used cDNA …

Peptides released in the spinal cord from the central terminals of nociceptors contribute to
the persistent hyperalgesia that defines the clinical experience of chronic pain. Using …

Vasoactive neuropeptides including substance P and calcitonin gene-related peptide
(CGRP) are localised in sensory nerves which innervate blood vessels. These are the major …

Recent molecular cloning studies by our laboratory and others have identified the existence
of a novel rat galanin receptor subtype, GALR2. In the present study, we examined the …

Many known painkillers are not always effective in the therapy of chronic neuropathic pain
manifested by hyperalgesia and tactile allodynia. The mechanisms underlying neuropathic …

In the nervous system, the neural cell adhesion molecule changes at the cell surface during
development, from a form highly enriched in polysialic residues to several isoforms …

Pituitary adenylate cyclase activating peptide (PACAP) is a vasoactive intestinal peptide-like
hypothalamic peptide occurring as two variants, PACAP-27 and the C-terminally extended …

Wrist and ankle fractures are the most frequent causes of complex regional pain syndrome
(CRPS type I). The current study examined the temporal development of vascular …

Background: The blood-brain barrier (BBB) plays the crucial role of limiting exposure of the
central nervous system (CNS) to damaging molecules and cells. Dysfunction of the BBB is …

Bone is the most common site of chronic pain in patients with metastatic cancer. What
remains unclear are the mechanisms that generate this pain and why bone cancer pain can …