A synthetic lethal interaction occurs between two genes when the perturbation of either gene
alone is viable but the perturbation of both genes simultaneously results in the loss of …

Genetic interactions identify combinations of genetic variants that impinge on phenotype.
With whole-genome sequence information available for thousands of individuals within a …

A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

The concept of synthetic lethality has been widely applied to identify therapeutic targets in
cancer, with varying degrees of success. The standard approach normally involves …

Background: Cells respond to environmental stressors through several key pathways,
including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA …

INTRODUCTION Genetic interactions are identified when variants in different genes
combine to generate an unusual phenotype compared with the expected combined effect of …

An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by
exploiting interactions between its driving mutations and specific drug targets. Here we use …

Little is known about how cells ensure DNA replication in the face of RNA polymerase II
(RNAPII)-mediated transcription, especially under conditions of replicative stress. Here we …

Histone modifications are major determinants of DNA double-strand break (DSB) response
and repair. Here we elucidate a DSB repair function for transcription-coupled Set2 …

Large-scale genetic perturbation screens are a classical approach in biology and have been
crucial for many discoveries. New technologies can now provide unbiased quantification of …