Decellularization of natural tissues to produce extracellular matrix is a promising method for
three-dimensional scaffolding and for understanding microenvironment of the tissue of …

During development, both cells and tissues must acquire the correct shape to allow their
proper function. This is especially relevant in the nervous system, where the shape of …

Injury to the central nervous system (CNS) alters the molecular and cellular composition of
neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons …

The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

The brain's extracellular matrix (ECM) is a macromolecular network composed of
glycosaminoglycans, proteoglycans, glycoproteins, and fibrous proteins. In vitro studies …

Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

Background Hostile environment around the lesion site following spinal cord injury (SCI)
prevents the re-establishment of neuronal tracks, thus significantly limiting the regenerative …

The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …

Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because
these act in parallel, no single intervention has been sufficient to enable full regeneration of …