Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications
D Salvemini, SF Kim, V Mollace - American Journal of …, 2013 - journals.physiology.org
The nitric oxide (NO) and cyclooxygenase (COX) pathways share a number of similarities.
Nitric oxide is the mediator generated from the NO synthase (NOS) pathway, and COX …
Nitric oxide is the mediator generated from the NO synthase (NOS) pathway, and COX …
Targeting the LKB1 tumor suppressor
RX Zhao, ZX Xu - Current drug targets, 2014 - ingentaconnect.com
LKB1 (also known as serine-threonine kinase 11, STK11) is a tumor suppressor, which is
mutated or deleted in Peutz-Jeghers syndrome (PJS) and in a variety of cancers …
mutated or deleted in Peutz-Jeghers syndrome (PJS) and in a variety of cancers …
Multi-target drugs: the trend of drug research and development
Summarizing the status of drugs in the market and examining the trend of drug research and
development is important in drug discovery. In this study, we compared the drug targets and …
development is important in drug discovery. In this study, we compared the drug targets and …
Nitric oxide synthase and cyclooxygenase pathways: a complex interplay in cellular signaling
A Sorokin - Current Medicinal Chemistry, 2016 - ingentaconnect.com
The cellular reaction to external challenges is a tightly regulated process consisting of
integrated processes mediated by a variety of signaling molecules, generated as a result of …
integrated processes mediated by a variety of signaling molecules, generated as a result of …
Cancer chemoprevention with green tea catechins: from bench to bed
Y Shirakami, M Shimizu, H Moriwaki - Current drug targets, 2012 - ingentaconnect.com
Many epidemiological studies and a large number of experimental studies using a variety of
animal models have observed that consumption or administration of green tea appears to …
animal models have observed that consumption or administration of green tea appears to …
Biomarkers of parathyroid carcinoma
The diagnosis of parathyroid carcinoma can be challenging, and adjuvant therapies such as
radiotherapy and chemotherapy are not particularly beneficial in the management of this …
radiotherapy and chemotherapy are not particularly beneficial in the management of this …
Simultaneous inhibition of EGFR/VEGFR and cyclooxygenase-2 targets stemness-related pathways in colorectal cancer cells
A Valverde, J Peñarando, A Cañas… - PLoS …, 2015 - journals.plos.org
Despite the demonstrated benefits of anti-EGFR/VEGF targeted therapies in metastatic
colorectal cancer (mCRC), many patients initially respond, but then show evidence of …
colorectal cancer (mCRC), many patients initially respond, but then show evidence of …
OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing
L Booth, SC Cazanave, HA Hamed… - Cancer biology & …, 2012 - Taylor & Francis
We have further defined mechanism (s) by which the drug OSU-03012 (OSU) kills tumor
cells. OSU lethality was suppressed by knock down of PERK and enhanced by knock down …
cells. OSU lethality was suppressed by knock down of PERK and enhanced by knock down …
Association of PYGO2 and EGFR in esophageal squamous cell carcinoma
Wnt signaling is an important evolutionary conserved pathway that is not only involved in
determination of cellular development, self-renewal, and fate, but also has significant roles …
determination of cellular development, self-renewal, and fate, but also has significant roles …
Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells
M Ahmed, AR Hussain, AK Siraj, S Uddin, N Al-Sanea… - Molecular cancer, 2015 - Springer
Background Cross-talk between deregulated signaling pathways in cancer cells causes
uncontrolled growth and proliferation. These cancers cells become more aggressive and …
uncontrolled growth and proliferation. These cancers cells become more aggressive and …