Mammals expend energy in many ways, including basic cellular maintenance and repair,
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …

Central dopaminergic mechanisms are involved in the motivational aspects of eating and
food choices. This review focuses on human and animal data investigating the importance of …

The arcuate nucleus of the hypothalamus (ARH) is a key component of hypothalamic
pathways regulating energy balance, and leptin is required for normal development of ARH …

Epidemiological studies in humans suggest that maternal undernutrition, obesity and
diabetes during gestation and lactation can all produce obesity in offspring. Animal models …

Background Obesity stems from a prolonged imbalance between the levels of energy intake
and expenditure, with the resultant surplus being stored as body lipids. Our understanding of …

Rats selectively bred to develop diet-induced obesity (DIO) were compared with those bred
to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin …

There is growing evidence that the postnatal environment can have a major impact on the
development of obesity and insulin resistance in offspring. We postulated that cross …

The availability of useful animal models reflecting the human obesity syndrome is crucial in
the search for novel compounds for the pharmacological treatment of obesity. In the current …

Overnutrition, such as a high-fat (HF) diet, is a feature followed by some in developed
nations that leads to obesity and fatty liver disease. In rats, when fed a fat-high diet, some …

The effects of running wheel exercise and caloric restriction on the regulation of body
weight, adiposity, and hypothalamic neuropeptide expression were compared in diet …