The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives
Mammals expend energy in many ways, including basic cellular maintenance and repair,
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …
Dopamine and binge eating behaviors
NT Bello, A Hajnal - Pharmacology Biochemistry and behavior, 2010 - Elsevier
Central dopaminergic mechanisms are involved in the motivational aspects of eating and
food choices. This review focuses on human and animal data investigating the importance of …
food choices. This review focuses on human and animal data investigating the importance of …
Hypothalamic neural projections are permanently disrupted in diet-induced obese rats
The arcuate nucleus of the hypothalamus (ARH) is a key component of hypothalamic
pathways regulating energy balance, and leptin is required for normal development of ARH …
pathways regulating energy balance, and leptin is required for normal development of ARH …
Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis
BE Levin - … Transactions of the Royal Society B …, 2006 - royalsocietypublishing.org
Epidemiological studies in humans suggest that maternal undernutrition, obesity and
diabetes during gestation and lactation can all produce obesity in offspring. Animal models …
diabetes during gestation and lactation can all produce obesity in offspring. Animal models …
[PDF][PDF] Animal models of obesity.
Background Obesity stems from a prolonged imbalance between the levels of energy intake
and expenditure, with the resultant surplus being stored as body lipids. Our understanding of …
and expenditure, with the resultant surplus being stored as body lipids. Our understanding of …
Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset
BE Levin, AA Dunn-Meynell… - American Journal of …, 2004 - journals.physiology.org
Rats selectively bred to develop diet-induced obesity (DIO) were compared with those bred
to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin …
to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin …
Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance
JN Gorski, AA Dunn-Meynell… - American Journal of …, 2006 - journals.physiology.org
There is growing evidence that the postnatal environment can have a major impact on the
development of obesity and insulin resistance in offspring. We postulated that cross …
development of obesity and insulin resistance in offspring. We postulated that cross …
[PDF][PDF] Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome
AN Madsen, G Hansen, SJ Paulsen… - Journal of …, 2010 - researchgate.net
The availability of useful animal models reflecting the human obesity syndrome is crucial in
the search for novel compounds for the pharmacological treatment of obesity. In the current …
the search for novel compounds for the pharmacological treatment of obesity. In the current …
[HTML][HTML] Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model
X Zhang, D Zhou, R Strakovsky… - American Journal of …, 2012 - journals.physiology.org
Overnutrition, such as a high-fat (HF) diet, is a feature followed by some in developed
nations that leads to obesity and fatty liver disease. In rats, when fed a fat-high diet, some …
nations that leads to obesity and fatty liver disease. In rats, when fed a fat-high diet, some …
Chronic exercise lowers the defended body weight gain and adiposity in diet-induced obese rats
BE Levin, AA Dunn-Meynell - American Journal of …, 2004 - journals.physiology.org
The effects of running wheel exercise and caloric restriction on the regulation of body
weight, adiposity, and hypothalamic neuropeptide expression were compared in diet …
weight, adiposity, and hypothalamic neuropeptide expression were compared in diet …