The molecular mechanisms of liver fibrosis and its potential therapy in application

D Zhang, Y Zhang, B Sun - International Journal of Molecular Sciences, 2022 - mdpi.com
Liver fibrosis results from repeated and persistent liver damage. It can start with hepatocyte
injury and advance to inflammation, which recruits and activates additional liver immune …

Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment

X Yang, Q Li, W Liu, C Zong, L Wei, Y Shi… - Cellular & Molecular …, 2023 - nature.com
Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or
hepatocellular carcinoma (HCC) and accounting for many deaths each year. The …

Hair follicle-MSC-derived small extracellular vesicles as a novel remedy for acute pancreatitis

S Li, H Li, H Zhangdi, R Xu, X Zhang, J Liu, Y Hu… - Journal of Controlled …, 2022 - Elsevier
Background Hair follicle-derived mesenchymal stem cell (HF-MSC)-based therapies protect
against acute pancreatitis (AP). However, accumulating evidence suggests that MSC-based …

Multiple dimensions of using mesenchymal stem cells for treating liver diseases: From bench to beside

L Chen, N Zhang, Y Huang, Q Zhang, Y Fang… - Stem Cell Reviews and …, 2023 - Springer
Liver diseases impose a huge burden worldwide. Although hepatocyte transplantation has
long been considered as a potential strategy for treating liver diseases, its clinical …

From Hair to Colon: Hair Follicle‐Derived MSCs Alleviate Pyroptosis in DSS‐Induced Ulcerative Colitis by Releasing Exosomes in a Paracrine Manner

Y Chang, Y Zhang, Y Jiang, L Zhao… - Oxidative Medicine …, 2022 - Wiley Online Library
Ulcerative colitis (UC) has attracted intense attention due to its high recurrence rate and the
difficulty of treatment. Pyroptosis has been suggested to be crucial in the development of …

BMSCs overexpressed ISL1 reduces the apoptosis of islet cells through ANLN carrying exosome, INHBA, and caffeine

Y Wang, JW Zhang, JW Wang, JL Wang… - Cellular and Molecular …, 2022 - Springer
Early apoptosis of grafted islets is one of the main factors affecting the efficacy of islet
transplantation. The combined transplantation of islet cells and bone marrow mesenchymal …

Surgical implantation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats

M Nomura, J George, C Hashizume, T Saito, Y Ueda… - Molecular …, 2022 - Springer
Abstract Background Mesenchymal stem cells (MSCs) are multipotent stromal cells and
could exert hepatoprotective effects against acute liver injury, steatohepatitis, and …

HGF-modified human umbilical cord mesenchymal stem cells rescue impaired ovarian reserve function in chemotherapy-induced POI rats by improving angiogenesis …

J Chen, Z Jia, F Zhang, C Han, L Zhao, Y Jia, M Cui - Tissue and Cell, 2023 - Elsevier
Complications caused by Primary ovarian insufficiency (POI), including infertility,
osteoporosis, cardiovascular diseases and depression, severely affect the life quality of …

Advance of Mesenchymal Stem Cells in Chronic End‐Stage Liver Disease Control

Y Gao, X Yin, X Ren - Stem Cells International, 2022 - Wiley Online Library
The chronic liver diseases will slowly develop into liver fibrosis, cirrhosis, and even liver
cancer if no proper control is performed with high efficiency. Up to now, the most effective …

BMSCs alleviate liver cirrhosis by regulating Fstl1/Wnt/β-Catenin signaling pathway

H Zhangdi, X Geng, N Li, R Xu, Y Hu, J Liu, X Zhang… - Heliyon, 2023 - cell.com
Researchers have shown that bone mesenchymal stem cells (BMSCs) can alleviate the
progression of liver cirrhosis; however, it is unclear how exactly BMSCs function to cure liver …