[HTML][HTML] A review of feature selection methods for machine learning-based disease risk prediction
N Pudjihartono, T Fadason, AW Kempa-Liehr… - Frontiers in …, 2022 - frontiersin.org
Machine learning has shown utility in detecting patterns within large, unstructured, and
complex datasets. One of the promising applications of machine learning is in precision …
complex datasets. One of the promising applications of machine learning is in precision …
[HTML][HTML] The genetics of polycystic ovary syndrome: an overview of candidate gene systematic reviews and genome-wide association studies
Polycystic Ovary Syndrome (PCOS) is a complex condition with mechanisms likely to involve
the interaction between genetics and lifestyle. Familial clustering of PCOS symptoms is well …
the interaction between genetics and lifestyle. Familial clustering of PCOS symptoms is well …
[HTML][HTML] A survey about methods dedicated to epistasis detection
During the past decade, findings of genome-wide association studies (GWAS) improved our
knowledge and understanding of disease genetics. To date, thousands of SNPs have been …
knowledge and understanding of disease genetics. To date, thousands of SNPs have been …
Deep neural network improves the estimation of polygenic risk scores for breast cancer
A Badré, L Zhang, W Muchero, JC Reynolds… - Journal of Human …, 2021 - nature.com
Polygenic risk scores (PRS) estimate the genetic risk of an individual for a complex disease
based on many genetic variants across the whole genome. In this study, we compared a …
based on many genetic variants across the whole genome. In this study, we compared a …
Genetic and environmental risk factors for developmental dyslexia in children: Systematic review of the last decade
N Becker, M Vasconcelos, V Oliveira… - Developmental …, 2017 - Taylor & Francis
Despite advances in the characterization of developmental dyslexia (DD), several questions
regarding the interplay between DD-susceptibility genes and environmental risk factors …
regarding the interplay between DD-susceptibility genes and environmental risk factors …
[HTML][HTML] Genome-Wide Association Studies of Salt Tolerance at Seed Germination and Seedling Stages in Brassica napus
Most crops are sensitive to salt stress, but their degree of susceptibility varies among
species and cultivars. In order to understand the salt stress adaptability of Brassica napus to …
species and cultivars. In order to understand the salt stress adaptability of Brassica napus to …
[HTML][HTML] Robust SNP-based prediction of rheumatoid arthritis through machine-learning-optimized polygenic risk score
AJW Lim, CT Tyniana, LJ Lim, JWL Tan, ET Koh… - Journal of Translational …, 2023 - Springer
Background The popular statistics-based Genome-wide association studies (GWAS) have
provided deep insights into the field of complex disorder genetics. However, its clinical …
provided deep insights into the field of complex disorder genetics. However, its clinical …
[HTML][HTML] sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
Meta-analysis has been established as an effective approach to combining summary
statistics of several genome-wide association studies (GWAS). However, the accuracy of …
statistics of several genome-wide association studies (GWAS). However, the accuracy of …
Drug response in association with pharmacogenomics and pharmacomicrobiomics: towards a better personalized medicine
R Hassan, I Allali, FE Agamah… - Briefings in …, 2021 - academic.oup.com
Researchers have long been presented with the challenge imposed by the role of genetic
heterogeneity in drug response. For many years, Pharmacogenomics and …
heterogeneity in drug response. For many years, Pharmacogenomics and …
[HTML][HTML] Weighted single-step GWAS identified candidate genes associated with semen traits in a Duroc boar population
N Gao, Y Chen, X Liu, Y Zhao, L Zhu, A Liu, W Jiang… - BMC genomics, 2019 - Springer
Background In the pig production industry, artificial insemination (AI) plays an important role
in enlarging the beneficial impact of elite boars. Understanding the genetic architecture and …
in enlarging the beneficial impact of elite boars. Understanding the genetic architecture and …