[HTML][HTML] A review of feature selection methods for machine learning-based disease risk prediction

N Pudjihartono, T Fadason, AW Kempa-Liehr… - Frontiers in …, 2022 - frontiersin.org
Machine learning has shown utility in detecting patterns within large, unstructured, and
complex datasets. One of the promising applications of machine learning is in precision …

[HTML][HTML] The genetics of polycystic ovary syndrome: an overview of candidate gene systematic reviews and genome-wide association studies

D Hiam, A Moreno-Asso, HJ Teede, JSE Laven… - Journal of clinical …, 2019 - mdpi.com
Polycystic Ovary Syndrome (PCOS) is a complex condition with mechanisms likely to involve
the interaction between genetics and lifestyle. Familial clustering of PCOS symptoms is well …

[HTML][HTML] A survey about methods dedicated to epistasis detection

C Niel, C Sinoquet, C Dina, G Rocheleau - Frontiers in genetics, 2015 - frontiersin.org
During the past decade, findings of genome-wide association studies (GWAS) improved our
knowledge and understanding of disease genetics. To date, thousands of SNPs have been …

Deep neural network improves the estimation of polygenic risk scores for breast cancer

A Badré, L Zhang, W Muchero, JC Reynolds… - Journal of Human …, 2021 - nature.com
Polygenic risk scores (PRS) estimate the genetic risk of an individual for a complex disease
based on many genetic variants across the whole genome. In this study, we compared a …

Genetic and environmental risk factors for developmental dyslexia in children: Systematic review of the last decade

N Becker, M Vasconcelos, V Oliveira… - Developmental …, 2017 - Taylor & Francis
Despite advances in the characterization of developmental dyslexia (DD), several questions
regarding the interplay between DD-susceptibility genes and environmental risk factors …

[HTML][HTML] Genome-Wide Association Studies of Salt Tolerance at Seed Germination and Seedling Stages in Brassica napus

G Zhang, J Zhou, Y Peng, Z Tan, L Li, L Yu… - Frontiers in Plant …, 2022 - frontiersin.org
Most crops are sensitive to salt stress, but their degree of susceptibility varies among
species and cultivars. In order to understand the salt stress adaptability of Brassica napus to …

[HTML][HTML] Robust SNP-based prediction of rheumatoid arthritis through machine-learning-optimized polygenic risk score

AJW Lim, CT Tyniana, LJ Lim, JWL Tan, ET Koh… - Journal of Translational …, 2023 - Springer
Background The popular statistics-based Genome-wide association studies (GWAS) have
provided deep insights into the field of complex disorder genetics. However, its clinical …

[HTML][HTML] sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies

R Nasirigerdeh, R Torkzadehmahani, J Matschinske… - Genome Biology, 2022 - Springer
Meta-analysis has been established as an effective approach to combining summary
statistics of several genome-wide association studies (GWAS). However, the accuracy of …

Drug response in association with pharmacogenomics and pharmacomicrobiomics: towards a better personalized medicine

R Hassan, I Allali, FE Agamah… - Briefings in …, 2021 - academic.oup.com
Researchers have long been presented with the challenge imposed by the role of genetic
heterogeneity in drug response. For many years, Pharmacogenomics and …

[HTML][HTML] Weighted single-step GWAS identified candidate genes associated with semen traits in a Duroc boar population

N Gao, Y Chen, X Liu, Y Zhao, L Zhu, A Liu, W Jiang… - BMC genomics, 2019 - Springer
Background In the pig production industry, artificial insemination (AI) plays an important role
in enlarging the beneficial impact of elite boars. Understanding the genetic architecture and …