Diabetic cardiomyopathy is a major complication of diabetes mellitus (DM). Currently,
effective treatments for diabetic cardiomyopathy are limited. The pathophysiology of diabetic …

Peroxisome proliferator‐activated receptors (PPARs) belong to the nuclear family of ligand
activated transcriptional factors and comprise three different isoforms, PPAR‐α, PPAR‐β/δ …

Diabetes mellitus (DM) has significant effects on cardiac calcium (Ca2+) and sodium (Na+)
regulation. Clinical studies have shown that empagliflozin (Jardiance™) has cardiovascular …

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2
inhibitors (SGLT2is) are antihyperglycemic agents with cardioprotective properties against …

Purpose Although increased oxidative stress is a major component of diabetic hypertensive
cardiomyopathy, research into the effects of antioxidants on cardiac remodeling remains …

Cardiac fibrosis is a pathogenic factor in a variety of cardiovascular diseases and is
characterized by an abnormal accumulation of extracellular matrix protein that leads to …

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among
patients with diabetes mellitus (DM). Chronic inflammation and derangement of myocardial …

Peroxisome proliferator‐activated receptors (PPARs) regulate cardiac glucose and lipid
homeostasis. Histone deacetylase (HDAC) inhibitor has anti‐inflammatory effects which may …

The active ingredients in many traditional Chinese medicines are isoprene oligomers with a
diterpenoid or triterpenoid structure, which exert cardiovascular effects by signalling through …

Background In diabetes mellitus the morbidity and mortality of cardiovascular disease is
increased and represents an important independent mechanism by which heart disease is …