[HTML][HTML] Biological and clinical aspects of HPV-related cancers

KA Szymonowicz, J Chen - Cancer biology & medicine, 2020 - ncbi.nlm.nih.gov
Cancer-related diseases represent the second overall cause of death worldwide. Human
papilloma virus (HPV) is an infectious agent which is mainly sexually transmitted and may …

Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues

D Boda, AO Docea, D Calina… - International …, 2018 - spandidos-publications.com
Human papilloma viruses (HPV) are a small group of non‑enveloped viruses belonging to
the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles …

[HTML][HTML] Immune signature-based subtypes of cervical squamous cell carcinoma tightly associated with human papillomavirus type 16 expression, molecular features …

X Lu, L Jiang, L Zhang, Y Zhu, W Hu, J Wang, X Ruan… - Neoplasia, 2019 - Elsevier
Substantial heterogeneity exists within cervical cancer that is generally infected by human
papillomavirus (HPV). However, the most common histological subtype of cervical cancer …

Enhanced radiation sensitivity in HPV-positive head and neck cancer

RJ Kimple, MA Smith, GC Blitzer, AD Torres, JA Martin… - Cancer research, 2013 - AACR
Patients with human papillomavirus (HPV+)–associated head and neck cancer (HNC) show
significantly improved survival outcome compared with those with HPV-negative (HPV−) …

HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity

T Rieckmann, S Tribius, TJ Grob, F Meyer… - Radiotherapy and …, 2013 - Elsevier
BACKGROUND AND PURPOSE: When treated by radiotherapy, patients with squamous
cell carcinomas of the head and neck (HNSCC) positive for HPV and p16INK4a possess a …

HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis

C Pan, N Issaeva, WG Yarbrough - Cancers of the head & neck, 2018 - Springer
Understanding of oropharyngeal squamous cell carcinoma has significantly progressed
over the last decades, and the concept that this disease can be subdivided into two distinct …

HPV positive head and neck cancers: molecular pathogenesis and evolving treatment strategies

R Dok, S Nuyts - Cancers, 2016 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that
is the result of tobacco and/or alcohol abuse or infection with high-risk Human …

HPV, hypoxia and radiation response in head and neck cancer

EL Göttgens, C Ostheimer, PN Span… - The British journal of …, 2018 - academic.oup.com
Over the last decades, the incidence of human papilloma virus (HPV) positive head and
neck squamous-cell carcinoma (HNSCC) has significantly increased. Infection with high-risk …

[HTML][HTML] Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity

CM Nickson, P Moori, RJ Carter, CP Rubbi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Patients with human papillomavirus type 16 (HPV)-associated oropharyngeal squamous cell
carcinomas (OPSCC) display increased sensitivity to radiotherapy and improved survival …

IL-6/STAT3 signaling in tumor cells restricts the expression of frameshift-derived neoantigens by SMG1 induction

D Meraviglia-Crivelli, H Villanueva, A Zheleva… - Molecular cancer, 2022 - Springer
Background The quality and quantity of tumor neoantigens derived from tumor mutations
determines the fate of the immune response in cancer. Frameshift mutations elicit better …