Mechanisms of oncogene-induced replication stress: jigsaw falling into place

P Kotsantis, E Petermann, SJ Boulton - Cancer discovery, 2018 - AACR
Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …

[HTML][HTML] Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease

H Mahboubi, U Stochaj - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Stress granule (SG) assembly is a conserved cellular strategy to minimize stress-related
damage and promote cell survival. Beyond their fundamental role in the stress response …

Two-Dimensional MXene-Originated In Situ Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy

M Zhang, D Yang, C Dong, H Huang, G Feng, Q Chen… - ACS …, 2022 - ACS Publications
Despite the merits of high tissue-penetrating depth, no ionizing radiation, and low cost,
sonodynamic therapy (SDT) still suffers from a low quantum yield of reactive oxygen species …

HTLV-1 infection and adult T-cell leukemia/lymphoma—a tale of two proteins: tax and HBZ

CZ Giam, OJ Semmes - Viruses, 2016 - mdpi.com
HTLV-1 (Human T-cell lymphotropic virus type 1) is a complex human delta retrovirus that
currently infects 10–20 million people worldwide. While HTLV-1 infection is generally …

Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

Activation of the DNA damage response by RNA viruses

EL Ryan, R Hollingworth, RJ Grand - Biomolecules, 2016 - mdpi.com
RNA viruses are a genetically diverse group of pathogens that are responsible for some of
the most prevalent and lethal human diseases. Numerous viruses introduce DNA damage …

[PDF][PDF] Ubiquitin‐specific peptidase 10 (USP10) inhibits hepatic steatosis, insulin resistance, and inflammation through Sirt6

P Luo, C Qin, L Zhu, C Fang, Y Zhang, H Zhang… - …, 2018 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance and inflammation, and the pathogenic mechanism of NAFLD is poorly …

Who regulates whom? An overview of RNA granules and viral infections

N Poblete-Durán, Y Prades-Pérez, J Vera-Otarola… - Viruses, 2016 - mdpi.com
After viral infection, host cells respond by mounting an anti-viral stress response in order to
create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation …

Functional analysis of deubiquitylating enzymes in tumorigenesis and development

J Cheng, J Guo, BJ North, B Wang, CP Cui, H Li… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …

The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53

C Hu, M Zhang, N Moses, C Hu, L Polin, W Chen… - Cell death & …, 2020 - nature.com
Abstract Ubiquitin-specific peptidase 10 (USP10) stabilizes both tumor suppressors and
oncogenes in a context-dependent manner. However, the nature of USP10's role in non …