Mechanisms of oncogene-induced replication stress: jigsaw falling into place
P Kotsantis, E Petermann, SJ Boulton - Cancer discovery, 2018 - AACR
Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …
of changes in the genome that contribute to genomic instability, which accelerates mutation …
[HTML][HTML] Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease
H Mahboubi, U Stochaj - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Stress granule (SG) assembly is a conserved cellular strategy to minimize stress-related
damage and promote cell survival. Beyond their fundamental role in the stress response …
damage and promote cell survival. Beyond their fundamental role in the stress response …
Two-Dimensional MXene-Originated In Situ Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy
M Zhang, D Yang, C Dong, H Huang, G Feng, Q Chen… - ACS …, 2022 - ACS Publications
Despite the merits of high tissue-penetrating depth, no ionizing radiation, and low cost,
sonodynamic therapy (SDT) still suffers from a low quantum yield of reactive oxygen species …
sonodynamic therapy (SDT) still suffers from a low quantum yield of reactive oxygen species …
HTLV-1 infection and adult T-cell leukemia/lymphoma—a tale of two proteins: tax and HBZ
HTLV-1 (Human T-cell lymphotropic virus type 1) is a complex human delta retrovirus that
currently infects 10–20 million people worldwide. While HTLV-1 infection is generally …
currently infects 10–20 million people worldwide. While HTLV-1 infection is generally …
Activation of the DNA damage response by RNA viruses
EL Ryan, R Hollingworth, RJ Grand - Biomolecules, 2016 - mdpi.com
RNA viruses are a genetically diverse group of pathogens that are responsible for some of
the most prevalent and lethal human diseases. Numerous viruses introduce DNA damage …
the most prevalent and lethal human diseases. Numerous viruses introduce DNA damage …
[PDF][PDF] Ubiquitin‐specific peptidase 10 (USP10) inhibits hepatic steatosis, insulin resistance, and inflammation through Sirt6
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance and inflammation, and the pathogenic mechanism of NAFLD is poorly …
resistance and inflammation, and the pathogenic mechanism of NAFLD is poorly …
Who regulates whom? An overview of RNA granules and viral infections
N Poblete-Durán, Y Prades-Pérez, J Vera-Otarola… - Viruses, 2016 - mdpi.com
After viral infection, host cells respond by mounting an anti-viral stress response in order to
create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation …
create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation …
Functional analysis of deubiquitylating enzymes in tumorigenesis and development
Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …
The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53
C Hu, M Zhang, N Moses, C Hu, L Polin, W Chen… - Cell death & …, 2020 - nature.com
Abstract Ubiquitin-specific peptidase 10 (USP10) stabilizes both tumor suppressors and
oncogenes in a context-dependent manner. However, the nature of USP10's role in non …
oncogenes in a context-dependent manner. However, the nature of USP10's role in non …