Ten-year follow-up of radiation therapy oncology group protocol 92-02: a phase III trial of the duration of elective androgen deprivation in locally advanced prostate …
EM Horwitz, K Bae, GE Hanks, A Porter… - Journal of Clinical …, 2008 - ascopubs.org
Purpose To determine whether adding 2 years of androgen-deprivation therapy (ADT)
improved outcome for patients electively treated with ADT before and during radiation …
improved outcome for patients electively treated with ADT before and during radiation …
CasodexTM 10–200 mg Daily, Used as Monotherapy for the Treatment of Patients with Advanced Prostate Cancer: An Overview of the Efficacy, Tolerability and …
CJ Tyrrell, L Denis, D Newling, M Soloway… - European …, 1998 - karger.com
Objectives: To evaluate the efficacy, tolerability, endocrinological effects and the
pharmacokinetics of CasodexTM, when given as monotherapy during daily dosing of 10 …
pharmacokinetics of CasodexTM, when given as monotherapy during daily dosing of 10 …
Nical benefits of bicalutamide compared with flutamide in combined androgen blockade for patients with advanced prostatic carcinoma: Final report of a double-blind …
PF Schellhammer, R Sharifi, NL Block, MS Soloway… - Urology, 1997 - Elsevier
OBJECTIVES: To compare the efficacy and tolerability of bicalutamide and flutamide, each
combined with luteinizing hormone-releasing hormone analogue (LHRH-A) therapy, in …
combined with luteinizing hormone-releasing hormone analogue (LHRH-A) therapy, in …
An overview of the clinical safety experience of first-and second-generation antisense oligonucleotides
TJ Kwoh - Antisense drug technology, 2007 - taylorfrancis.com
Helping patients by finding new therapeutic agents that specifically reduce the key protein
causing the patient's condition/disease is a major theme in current pharmaceutical discovery …
causing the patient's condition/disease is a major theme in current pharmaceutical discovery …
Tolerability of nonsteroidal antiandrogens in the treatment of advanced prostate cancer
DG McLeod - The oncologist, 1997 - academic.oup.com
This review compares the tolerability profiles of the three currently available nonsteroidal
antiandrogens, flutamide, bicalutamide and nilutamide. Pharmacological effects associated …
antiandrogens, flutamide, bicalutamide and nilutamide. Pharmacological effects associated …
Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats
F Mannaa, HH Ahmed, SF Estefan… - Die Pharmazie-An …, 2005 - ingentaconnect.com
The aim of this work was to investigate the protective role of baker's yeast Saccharomyces
cerevisiae against the hepatotoxic effect of the drug flutamide that is widely used for …
cerevisiae against the hepatotoxic effect of the drug flutamide that is widely used for …
Tri-Modality therapy with I-125 brachytherapy, external beam radiation therapy, and short-or long-term hormone therapy for high-risk localized prostate cancer (TRIP) …
H Konaka, S Egawa, S Saito, A Yorozu, H Takahashi… - BMC cancer, 2012 - Springer
Abstract Background Patients with high Gleason score, elevated prostate specific antigen
(PSA) level, and advanced clinical stage are at increased risk for both local and systemic …
(PSA) level, and advanced clinical stage are at increased risk for both local and systemic …
[PDF][PDF] Randomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifen
Groupe d'Etude et de Traitement du Carcinome … - …, 2004 - Wiley Online Library
The growth of hepatocellular carcinoma (HCC) is thought to be dependent on androgens, as
androgen receptors are present in most of these tumors. The aim of this multicenter trial was …
androgen receptors are present in most of these tumors. The aim of this multicenter trial was …
Is there a role for antiandrogen monotherapy in patients with metastatic prostate cancer?
AV Kaisary, P Iversen, CJ Tyrrell, K Carroll… - Prostate Cancer and …, 2001 - nature.com
Castration is the most widely used form of androgen ablation employed in the treatment of
metastatic (M1) prostate cancer. Non-steroidal antiandrogen monotherapy is a potential …
metastatic (M1) prostate cancer. Non-steroidal antiandrogen monotherapy is a potential …
Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis
WH Kan, CH Hsieh, MG Schwacha… - Journal of applied …, 2008 - journals.physiology.org
Although studies have shown that administration of testosterone receptor antagonist,
flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune …
flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune …