[HTML][HTML] Prevention strategies for sexually transmitted infections, HIV, and viral hepatitis in Europe

D Gökengin, T Noori, A Alemany… - The Lancet Regional …, 2023 - thelancet.com
The current prevention efforts for STIs, HIV and viral hepatitis in the WHO European Region,
especially in the Central and Eastern subregions, are hindered by healthcare disparities …

[HTML][HTML] Chlamydia trachomatis as a Current Health Problem: Challenges and Opportunities

R Rodrigues, C Sousa, N Vale - Diagnostics, 2022 - mdpi.com
Chlamydia is one of the most common sexually transmitted bacterial infections (STIs)
worldwide. It is caused by Chlamydia trachomatis (CT), which is an obligate intracellular …

[HTML][HTML] The inclusion membrane protein IncS is critical for initiation of the Chlamydia intracellular developmental cycle

ME Cortina, RC Bishop, BA DeVasure… - PLoS …, 2022 - journals.plos.org
All Chlamydia species are obligate intracellular bacteria that undergo a unique biphasic
developmental cycle strictly in the lumen of a membrane bound compartment, the inclusion …

[HTML][HTML] Preparation of graphene oxide–stabilized Pickering emulsion adjuvant for Pgp3 recombinant vaccine and enhanced immunoprotection against Chlamydia …

L Zhao, M Shu, H Chen, K Shi, Z Li - Frontiers in Immunology, 2023 - frontiersin.org
Background Traditional emulsion adjuvants are limited in clinical application because of
their surfactant dependence. Graphene oxide (GO) has unique amphiphilic properties and …

Homologues of the Chlamydia trachomatis and Chlamydia muridarum inclusion membrane protein IncS are interchangeable for early development but not for …

ME Cortina, I Derré - Msphere, 2023 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterium, which undergoes a biphasic
developmental cycle inside a vacuole termed the inclusion. Chlamydia-specific effector …

[HTML][HTML] A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens

KB Weyant, A Oloyede, S Pal, J Liao… - Nature …, 2023 - nature.com
Engineered outer membrane vesicles (OMVs) derived from Gram-negative bacteria are a
promising technology for the creation of non-infectious, nanoparticle vaccines against …

IL-23 receptor signaling licenses group 3-like innate lymphoid cells to restrict a live-attenuated oral Chlamydia vaccine in the gut

Y He, Y Wang, R He, AM Abdelsalam… - Infection and …, 2023 - Am Soc Microbiol
An IFNγ-susceptible mutant of Chlamydia muridarum is attenuated in pathogenicity in the
genital tract and was recently licensed as an intr acellular O ral vaccine v ector or intrOv …

Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

C Lu, J Wang, G Zhong - Infection and immunity, 2023 - Am Soc Microbiol
To search for subunit vaccine candidates, immunogenic chlamydial antigens identified in
humans were evaluated for protection against both infection and pathology in a mouse …

[HTML][HTML] Chlamydia trachomatis polymorphic membrane Proteins (Pmps) form functional homomeric and heteromeric oligomers

A Favaroni, JH Hegemann - Frontiers in Microbiology, 2021 - frontiersin.org
Chlamydiae are Gram-negative, obligate intracellular bacteria, which infect animals and
humans. Adhesion to host cells, the first step in the infection process, is mediated by …

Chlamydia trachomatis vaccine development – a view on the current challenges and how to move forward

ÁH Borges, F Follmann, J Dietrich - Expert Review of Vaccines, 2022 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. A licensed vaccine is not yet available, but the first vaccines have …