Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

Certain guanine-rich (G-rich) DNA and RNA molecules can associate intermolecularly or
intramolecularly to form four stranded or “quadruplex” structures, which have unusual …

Expansion of a hexanucleotide repeat GGGGCC (G 4 C 2) in C9ORF72 is the most common
cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Transcripts …

Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and
Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

AS1411 is a first-in-class anticancer agent, currently in phase II clinical trials. It is a
quadruplex-forming oligodeoxynucleotide that binds to nucleolin as an aptamer, but its …

We sought to determine whether nucleolin, a bcl-2 mRNA-binding protein, has a role in the
regulation of bcl-2 mRNA stability in MCF-7 and MDA-MB-231 breast cancer cells …

Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it
plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus …

Background Angiogenesis is the process of neovascularization from pre-existing
vasculature and is involved in various physiological and pathological processes. Inhibitors …

By its unique advantages over traditional medicine, nanomedicine has offered new
strategies for cancer treatment. In particular, the development of drug delivery strategies has …