By its unique advantages over traditional medicine, nanomedicine has offered new
strategies for cancer treatment. In particular, the development of drug delivery strategies has …

A tumor-homing peptide, F3, selectively binds to endothelial cells in tumor blood vessels
and to tumor cells. Here, we show that the cell surface molecule recognized by F3 is …

In this review, the authors describe a novel mechanism for control of MYC expression that
involves a four-stranded DNA structure, termed a G-quadruplex, amenable to small …

Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in
the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA …

Ribosomes and protein synthesis have been reported to be altered in the cerebral cortex at
advanced stages of Alzheimer's disease (AD). Modifications in the hippocampus with …

myc is a proto-oncogene that plays an important role in the promotion of cellular growth and
proliferation. Understanding the regulation of c-myc is important in cancer biology, as it is …

Nucleolin is multifunctional phosphoprotein ubiquitously distributed in the nucleolus,
nucleus and cytoplasm of the cell. Nucleolin has a bipartite nuclear localization signal …

We report the direct visualization of interactions between drug-loaded nanoparticles and the
cancer cell nucleus. Nanoconstructs composed of nucleolin-specific aptamers and gold …

Oligonucleotides have been extensively studied as antisense or antigene agents that can
potentially modulate the expression of specific genes. These strategies rely on sequence …

The myc oncogenes are frequently activated in human tumors, but there is no
comprehensive insight into the target genes and downstream cellular pathways of these …