The function of the nucleolus as a factory for assembling ribosomal subunits is well
established, but many unrelated activities have been discovered over the past decade. Our …

The plasmacytoma variant translocation 1 gene (PVT1) is an lncRNA that has been
designated as an oncogene due to its contribution to the phenotype of multiple cancers …

Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells
without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its …

Picornaviruses cause several diseases, not only in humans but also in various animal hosts.
For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina …

Background Nucleolin is one of the major proteins of the nucleolus, but it is also expressed
on the cell surface where is serves as a binding protein for variety of ligands implicated in …

The ARF tumor suppressor is a nucleolar protein that activates p53-dependent checkpoints
by binding Mdm2, a p53 antagonist. Despite persuasive evidence that ARF can bind and …

AGRO100, also known as AS1411, is an experimental anticancer drug that recently entered
human clinical trials. It is a member of a novel class of antiproliferative agents known as G …

The subcellular localization of transmissible gastroenteritis virus (TGEV) and mouse
hepatitis virus (MHV)(group I and group II coronaviruses, respectively) nucleoproteins (N …

The exact molecular mechanism of how endostatin inhibits angiogenesis and tumor growth
remains uncharacterized. Here, we report that endostatin specifically binds to the cell …

Remodeling machines play an essential role in the control of gene expression, but how their
activity is regulated is not known. Here we report that the nuclear protein nucleolin …