Cancer, one of the most mortal diseases worldwide, is characterized by the gain of specific
features and cellular heterogeneity. Clonal evolution is an established theory to explain …

Hepatitis C virus (HCV) infection is a major cause of human chronic liver disease and
hepatocellular carcinoma. G-quadruplex (G4) is an important four-stranded secondary …

RNA chaperones are ubiquitous and abundant proteins found in all living organisms and
viruses, where they interact with various classes of RNA. These highly diverse families of …

Compacted DNA nanoparticles deliver transgenes efficiently to the lung following
intrapulmonary dosing. Here we show that nucleolin, a protein known to shuttle between the …

In eukaryotes, 45S rRNA genes are arranged in tandem arrays in copy numbers ranging
from several hundred to several thousand in plants. Although it is clear that not all copies are …

Poliovirus disrupts nucleocytoplasmic trafficking and results in the cleavage of two nuclear
pore complex (NPC) proteins, Nup153 and Nup62. The NPC is a 125-MDa complex …

Background Neuroblastoma (NB) represents the most frequent and aggressive form of
extracranial solid tumor of infants. Nucleolin (NCL) is a protein overexpressed and partially …

Adenovirus infection inhibits synthesis and processing of rRNA and redistributes nucleolar
antigens. Adenovirus protein V associates with nucleoli in infected cells. This study …

MALAT1, an abundant lncRNA specifically localized to nuclear speckles, regulates
alternative-splicing (AS). The molecular basis of its role in AS remains poorly understood …

Ligand-receptor internalization has been traditionally regarded as part of the cellular
desensitization system. Low-density lipoprotein receptor-related protein (LRP) is a large …