Pancreatic ductal adenocarcinoma is associated with a poor prognosis and there are few
treatment options. The development of immunotherapy in pancreatic ductal adenocarcinoma …

Hyperthermic nanomedicines are particularly relevant for tackling human cancer, providing
a valuable alternative to conventional therapeutics. The early-stage preclinical performance …

Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a
crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated …

Oral squamous cell carcinoma (OSCC) is a prevalent form of malignant tumor, characterized
by a persistently high incidence and mortality rate. The extracellular matrix (ECM) plays a …

Simple Summary IDH-mutant low-grade gliomas (LGG) are slow-growing glial cell-derived
tumors of the central nervous system (CNS) that predominantly manifest in young adults and …

Using meta-analyses, we introduce a unicellular attractor (UCA) model integrating essential
features of the 'atavistic reversal','cancer attractor','somatic mutation','genome chaos', and …

The tumor microenvironment (TME) is crucial in cancer progression, and the extracellular
matrix (ECM) is an important TME component. Collagen is a major ECM component that …

This comprehensive review delves into the pivotal role of the tumor microenvironment (TME)
in cancer metastasis and therapeutic response, offering fresh insights into the intricate …

Proliferation and invasion are two key drivers of tumor growth that are traditionally
considered independent multicellular processes. However, these processes are intrinsically …

Radiation therapy is a highly effective method for inhibiting tumor growth and is widely used
in clinical settings. 1 It damages the vital biomolecules (especially DNA) of cancer cells and …