Probing neural circuit mechanisms in Alzheimer's disease using novel technologies
The study of Alzheimer's Disease (AD) has traditionally focused on neuropathological
mechanisms that has guided therapies that attenuate neuropathological features. A new …
mechanisms that has guided therapies that attenuate neuropathological features. A new …
Metalloproteinases and their tissue inhibitors in Alzheimer's disease and other neurodegenerative disorders
S Rivera, L García-González, M Khrestchatisky… - Cellular and Molecular …, 2019 - Springer
As life expectancy increases worldwide, age-related neurodegenerative diseases will
increase in parallel. The lack of effective treatment strategies may soon lead to an …
increase in parallel. The lack of effective treatment strategies may soon lead to an …
[PDF][PDF] LC3-associated endocytosis facilitates β-amyloid clearance and mitigates neurodegeneration in murine Alzheimer's disease
BL Heckmann, BJW Teubner, B Tummers… - Cell, 2019 - cell.com
The expression of some proteins in the autophagy pathway declines with age, which may
impact neurodegeneration in diseases, including Alzheimer's Disease. We have identified a …
impact neurodegeneration in diseases, including Alzheimer's Disease. We have identified a …
Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice
Oxidative damage including lipid peroxidation is widely reported in Alzheimer's disease
(AD) with the peroxidation of phospholipids in membranes being the driver of ferroptosis, an …
(AD) with the peroxidation of phospholipids in membranes being the driver of ferroptosis, an …
Visuo‐spatial learning and memory impairments in the 5xFAD mouse model of Alzheimer's disease: Effects of age, sex, albinism, and motor impairments
TP O'Leary, RE Brown - Genes, Brain and Behavior, 2022 - Wiley Online Library
The 5xFAD mouse model of Alzheimer's disease (AD) rapidly develops AD‐related neuro‐
behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not …
behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not …
Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease
V Landel, K Baranger, I Virard, B Loriod… - Molecular …, 2014 - Springer
Background The 5XFAD early onset mouse model of Alzheimer's disease (AD) is gaining
momentum. Behavioral, electrophysiological and anatomical studies have identified age …
momentum. Behavioral, electrophysiological and anatomical studies have identified age …
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease
K Baranger, Y Marchalant, AE Bonnet… - Cellular and Molecular …, 2016 - Springer
Abstract Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly
expressed in the nervous system with emerging roles in brain pathophysiology. The …
expressed in the nervous system with emerging roles in brain pathophysiology. The …
Glial cell reactivity and oxidative stress prevention in Alzheimer's disease mice model by an optimized NMDA receptor antagonist
J Companys-Alemany, AL Turcu, S Vázquez… - Scientific Reports, 2022 - nature.com
In Alzheimer's disease pathology, several neuronal processes are dysregulated by
excitotoxicity including neuroinflammation and oxidative stress (OS). New therapeutic …
excitotoxicity including neuroinflammation and oxidative stress (OS). New therapeutic …
[HTML][HTML] Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer's disease
A Jullienne, JI Szu, R Quan, MV Trinh… - Frontiers in Aging …, 2023 - ncbi.nlm.nih.gov
Methods Male and female 5xFAD and wild type (WT) littermates underwent in vivo 18 F-
fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging at 4, 6, and 12 …
fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging at 4, 6, and 12 …
Bridging the Gap between Gut Microbiota and Alzheimer's Disease: A Metaproteomic Approach for Biomarker Discovery in Transgenic Mice
Alzheimer's Disease (AD) is a progressively debilitating form of dementia that affects millions
of individuals worldwide. Although a vast amount of research has investigated the complex …
of individuals worldwide. Although a vast amount of research has investigated the complex …