Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic
stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are …

Liquid handling robots have the potential to automate many procedures in life sciences.
However, they are not in widespread use in academic settings, where funding, space and …

Rapid clonal expansion of antigen-specific T cells is a fundamental feature of adaptive
immune responses. It enables the outgrowth of an individual T cell into thousands of clonal …

Cells have evolved intricate mechanisms for dividing their contents in the most symmetric
way during mitosis. However, a small proportion of cell divisions results in asymmetric …

The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is
sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions …

Stem cells require high amounts of energy to replicate their genome and organelles and
differentiate into numerous cell types. Therefore, metabolic stress has a major impact on …

Cells can use signaling pathway activity over time (ie, dynamics) to control cell fates.
However, little is known about the potential existence and function of signaling dynamics in …

Tissue disorganisation is one of the main hallmarks of cancer. Polarity proteins are
responsible for the arrangement of cells within epithelial tissues through the asymmetric …

Background Adipose-derived stem cells (ADSCs) have been extensively used in preclinical
and clinical trials for treating various diseases. However, the differences between ADSCs …

Simple Summary Transplantation of adult hematopoietic stem cells is an important
therapeutic tool to help patients suffering from diverse hematological disorders. All types of …