The immunological and genetic basis of inflammatory bowel disease

G Bouma, W Strober - Nature reviews immunology, 2003 - nature.com
The inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, are chronic
inflammatory disorders of the gastrointestinal tract. Enormous progress has been made …

Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention

MG Tansey, MK McCoy, TC Frank-Cannon - Experimental neurology, 2007 - Elsevier
Most acute and chronic neurodegenerative conditions are accompanied by
neuroinflammation; yet the exact nature of the inflammatory processes and whether they …

Reduced Paneth cell α-defensins in ileal Crohn's disease

J Wehkamp, NH Salzman, E Porter… - Proceedings of the …, 2005 - National Acad Sciences
The pathogenesis of Crohn′ s disease (CD), an idiopathic inflammatory bowel disease, is
attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal …

[图书][B] Human evolutionary genetics: origins, peoples and disease

M Jobling, C Tyler-Smith - 2019 - taylorfrancis.com
Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression

J Wehkamp, J Harder, M Weichenthal, M Schwab… - Gut, 2004 - gut.bmj.com
Background: Mutations in NOD2, a putative intracellular receptor for bacterial
peptidoglycans, are associated with a subset of Crohn's disease but the molecular …

Rapid and noninvasive metabonomic characterization of inflammatory bowel disease

JR Marchesi, E Holmes, F Khan… - Journal of proteome …, 2007 - ACS Publications
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis
(UC) have a major impact on the health of individuals and populations. Accurate diagnosis …

Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa

NH Salzman, MA Underwood, CL Bevins - Seminars in immunology, 2007 - Elsevier
Mucosal surfaces are colonized by a diverse and dynamic microbiota. Much investigation
has focused on bacterial colonization of the intestine, home to the vast majority of this …

Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease

M Fasseu, X Tréton, C Guichard, E Pedruzzi… - PloS one, 2010 - journals.plos.org
Background Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic Inflammatory
Bowel Diseases (IBD) affecting the intestinal mucosa. Current understanding of IBD …

Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease

K Yamazaki, D McGovern, J Ragoussis… - Human molecular …, 2005 - academic.oup.com
The inflammatory bowel diseases (IBDs), Crohn's disease (CD) and ulcerative colitis, are
chronic inflammatory disorders of the digestive tract. The pathogenesis of IBD is …

Inflammatory bowel disease and smoking: a review of epidemiology, pathophysiology, and therapeutic implications

T Birrenbach, U Böcker - Inflammatory bowel diseases, 2004 - academic.oup.com
The relationship between smoking behavior and inflammatory bowel disease (IBD) is
complex. While Crohn's disease (CD) is associated with smoking and smoking has …