Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

[HTML][HTML] Cysteine metabolic circuitries: Druggable targets in cancer

VDB Bonifácio, SA Pereira, J Serpa… - British journal of cancer, 2021 - nature.com
To enable survival in adverse conditions, cancer cells undergo global metabolic
adaptations. The amino acid cysteine actively contributes to cancer metabolic remodelling …

Regulators of the transsulfuration pathway

JI Sbodio, SH Snyder, BD Paul - British journal of …, 2019 - Wiley Online Library
The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …

[HTML][HTML] Hydrogen sulfide biology and its role in cancer

S Khattak, MA Rauf, NH Khan, QQ Zhang, HJ Chen… - Molecules, 2022 - mdpi.com
Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian
tissues. It plays a very critical role in many pathophysiological processes in the body. It can …

[HTML][HTML] Hydrogen sulfide signaling in mitochondria and disease

B Murphy, R Bhattacharya, P Mukherjee - The FASEB Journal, 2019 - ncbi.nlm.nih.gov
Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …

A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator

C Szabo - Biochemical pharmacology, 2018 - Elsevier
The history of H 2 S–as an environmental toxin–dates back to 1700, to the observations of
the Italian physician Bernardino Ramazzini, whose book “De Morbis Artificum Diatriba” …

[HTML][HTML] Hydrogen sulfide and vascular regulation–An update

B Lv, S Chen, C Tang, H Jin, J Du, Y Huang - Journal of advanced research, 2021 - Elsevier
Abstract Background Hydrogen sulfide (H 2 S) is considered to be the third gasotransmitter
after carbon monoxide (CO) and nitric oxide (NO). It plays an important role in the regulation …

[HTML][HTML] Hydrogen sulfide biochemistry and interplay with other gaseous mediators in mammalian physiology

A Giuffrè, JB Vicente - Oxidative Medicine and Cellular Longevity, 2018 - hindawi.com
Hydrogen sulfide (H 2 S) has emerged as a relevant signaling molecule in physiology,
taking its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide …