The XRN family of 5′→ 3′ exoribonucleases is critical for ensuring the fidelity of cellular
RNA turnover in eukaryotes. Highly conserved across species, the family is typically …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Most DNA in the genomes of higher organisms does not encode proteins, yet much is
transcribed by RNA polymerase II (RNAPII) into long non-coding RNAs (lncRNAs). The …

Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the
cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act …

Antisense oligonucleotides (ASOs) that trigger RNase-H-mediated cleavage are commonly
used to knock down transcripts for experimental or therapeutic purposes. In particular, ASOs …

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …

All aspects of transcription and its regulation involve dynamic events. The basal transcription
machinery and regulatory components are dynamically recruited to their target genes, and …

ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises
multiple tandem conserved heptapeptide repeats, unique to this eukaryotic RNA …