Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses

SN Crooke, IG Ovsyannikova, GA Poland… - Experimental …, 2019 - Elsevier
Immunosenescence contributes to a decreased capacity of the immune system to respond
effectively to infections or vaccines in the elderly. The full extent of the biological changes …

The role of innate immunity in natural elite controllers of HIV-1 infection

Y Shi, J Su, R Chen, W Wei, Z Yuan, X Chen… - Frontiers in …, 2022 - frontiersin.org
The natural process of human immunodeficiency virus type 1 (HIV-1) infection is
characterized by high viral load, immune cell exhaustion, and immunodeficiency, which …

HIV-associated cellular senescence: a contributor to accelerated aging

J Cohen, C Torres - Ageing research reviews, 2017 - Elsevier
Due to the advent of antiretroviral therapy HIV is no longer a terminal disease and the HIV
infected patients are becoming increasingly older. While this is a major success, with …

Extrapolating understanding of food risk perceptions to emerging food safety cases

G Kaptan, ARH Fischer, LJ Frewer - Journal of Risk Research, 2018 - Taylor & Francis
Important determinants of risk perceptions associated with foods are the extent to which the
potential hazards are perceived to have technological or naturally occurring origins, together …

Patho-physiology of aging and immune-senescence: possible correlates with comorbidity and mortality in middle-aged and old COVID-19 patients

S Farheen, S Agrawal, S Zubair, A Agrawal… - Frontiers in …, 2021 - frontiersin.org
During the last 2 years, the entire world has been severely devastated by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic (COVID-19) as it resulted in …

Evidence for residual immunity to smallpox after vaccination and implications for re-emergence

MP Kunasekaran, X Chen, V Costantino… - Military …, 2019 - academic.oup.com
Introduction Smallpox has been eradicated but advances in synthetic biology have
increased the risk of its re-emergence. Residual immunity in individuals who were …

[HTML][HTML] Aged mice are more resistant to influenza virus infection due to reduced inflammation and lung pathology

J Lu, X Duan, W Zhao, J Wang, H Wang, K Zhou… - Aging and …, 2018 - ncbi.nlm.nih.gov
Immune responses are a double-edged sword. Effective and appropriate immune responses
capable of controlling viral infection while also largely preserving tissue integrity, are critical …

Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice

AA Felizardo, IS Caldas, AAS Mendonça… - Free Radical Biology …, 2018 - Elsevier
Elderly organisms are more susceptible to infectious diseases. However, the impact of aging
on antiparasitic mechanisms, especially the nitric oxide pathway, is poorly understood …

Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double‑blind, placebo-controlled clinical trial

AF Elsaid, M Shaheen… - Experimental and …, 2018 - spandidos-publications.com
Aging is associated with a decline in natural killer (NK) and natural killer T (NKT) cell
function that may contribute to increased susceptibility to malignancy and infection. A …