Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum

N Fine, S Lively, CA Séguin, AV Perruccio… - Nature Reviews …, 2023 - nature.com
Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …

[HTML][HTML] Cellular senescence–molecular mechanisms of intervertebral disc degeneration from an immune perspective

C Song, Y Zhou, K Cheng, F Liu, W Cai, D Zhou… - Biomedicine & …, 2023 - Elsevier
Intervertebral disc degeneration (IVDD) is a frequent and intractable chronic condition in
orthopedics that causes enormous discomfort in patients' lives and thoughts, as well as a …

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration

J Xu, T Shao, J Lou, J Zhang, C Xia - Frontiers in pharmacology, 2023 - frontiersin.org
Intervertebral disc degeneration (IVDD) refers to the aging and degenerative diseases of
intervertebral disc components such as nucleus pulposus, annulus fibrosus, and cartilage …

[HTML][HTML] Progress in regulating inflammatory biomaterials for intervertebral disc regeneration

H Xiang, W Zhao, K Jiang, J He, L Chen, W Cui, Y Li - Bioactive materials, 2024 - Elsevier
Intervertebral disc degeneration (IVDD) is rising worldwide and leading to significant health
issues and financial strain for patients. Traditional treatments for IVDD can alleviate pain but …

[HTML][HTML] Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by …

D Guo, K Cheng, C Song, F Liu, W Cai, J Chen… - International …, 2023 - Elsevier
Intervertebral disc degeneration (IVDD) is one of the leading causes of lower back pain and
the most common health problem in the world. Inflammasomes, which is mainly caused by …

Nucleus pulposus cell-derived efficient microcarrier for intervertebral disc tissue engineering

X Zhou, N Shen, Y Tao, J Wang, K Xia, L Ying… - …, 2023 - iopscience.iop.org
Adipose-derived stem cells (ADSCs) show great potential for the treatment of intervertebral
disc (IVD) degeneration. An ideal carrier is necessary to transplant ADSCs into degenerated …

[HTML][HTML] Mechanical stimulation promotes MSCs healing the lesion of intervertebral disc annulus fibrosus

R Deng, R Kang, X Jin, Z Wang, X Liu… - … in Bioengineering and …, 2023 - frontiersin.org
Mesenchymal stem cells (MSCs) and scaffolds offer promising perspectives for annulus
fibrosus (AF) repair. The repair effect was linked to features of the local mechanical …

[HTML][HTML] Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration

H Huang, X Liu, J Wang, M Suo, J Zhang… - Frontiers in Cell and …, 2023 - ncbi.nlm.nih.gov
Intervertebral disc degeneration is thought to be a major contributor to low back pain, the
etiology of which is complex and not yet fully understood. To compensate for the lack of drug …

Role of arachidonic acid metabolism in intervertebral disc degeneration: identification of potential biomarkers and therapeutic targets via multi-omics analysis and …

J Tan, M Shi, B Li, Y Liu, S Luo, X Cheng - Lipids in health and disease, 2023 - Springer
Background Intervertebral disc degeneration (IVDD) is widely recognized as the primary
etiological factor underlying low back pain, often necessitating surgical intervention as the …

[HTML][HTML] Application of mesenchymal stem cell-derived exosomes from different sources in intervertebral disc degeneration

Y Xia, R Yang, Y Hou, H Wang, Y Li, J Zhu… - … in bioengineering and …, 2022 - frontiersin.org
Intervertebral disc degeneration (IVDD) is a main cause of lower back pain, leading to
psychological and economic burdens to patients. Physical therapy only delays pain in …