Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of
thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge …

Antimicrobial peptides (AMPs) are expressed in various living organisms as first-line host
defenses against potential harmful encounters in their surroundings. AMPs are short …

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

▪ Abstract Bacterial lipopolysaccharides (LPS) typically consist of a hydrophobic domain
known as lipid A (or endotoxin), a nonrepeating “core” oligosaccharide, and a distal …

Almost one-third of all proteases can be classified as serine proteases, named for the
nucleophilic Ser residue at the active site. This mechanistic class was originally …

Bacterial lipopolysaccharides (LPS) are the major outer surface membrane components
present in almost all Gram-negative bacteria and act as extremely strong stimulators of …

Inflammation initiates clotting, decreases the activity of natural anticoagulant mechanisms
and impairs the fibrinolytic system. Inflammatory cytokines are the major mediators involved …

Thrombin is the pivotal enzyme in the biochemistry of secondary hemostasis crucial to
maintaining homeostasis of hemostasis. In contrast to routine coagulation tests (PT or aPTT) …

Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome
(ARDS), are syndromes of acute respiratory failure that result from acute pulmonary edema …

The placenta is a gender-specific transitory organ with the sole purpose of enabling the
growth and development of the fetus. It mediates the efficient transfer and exchange of …