[HTML][HTML] The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy

F Ardito, M Giuliani, D Perrone… - International …, 2017 - spandidos-publications.com
Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

P Seshacharyulu, P Pandey, K Datta, SK Batra - Cancer letters, 2013 - Elsevier
Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine
threonine phosphatase and regulates the function by dephosphorylating many critical …

Serine/threonine phosphatases: mechanism through structure

Y Shi - Cell, 2009 - cell.com
The reversible phosphorylation of proteins is accomplished by opposing activities of kinases
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …

Protein tyrosine phosphatases–from housekeeping enzymes to master regulators of signal transduction

NK Tonks - The FEBS journal, 2013 - Wiley Online Library
There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

Evolution and functional cross‐talk of protein post‐translational modifications

P Beltrao, P Bork, NJ Krogan… - Molecular systems …, 2013 - embopress.org
Protein post‐translational modifications (PTM s) allow the cell to regulate protein activity and
play a crucial role in the response to changes in external conditions or internal states …

Phosphoproteomics in the age of rapid and deep proteome profiling

NM Riley, JJ Coon - Analytical chemistry, 2016 - ACS Publications
Protein phosphorylation is a post-translational modification (PTM) that orchestrates a diverse
array of cellular processes. Because this modification serves as a rapid and reversible …

Protein Phosphatases 2C Regulate the Activation of the Snf1-Related Kinase OST1 by Abscisic Acid in Arabidopsis

F Vlad, S Rubio, A Rodrigues, C Sirichandra… - The Plant …, 2009 - academic.oup.com
The plant hormone abscisic acid (ABA) orchestrates plant adaptive responses to a variety of
stresses, including drought. This signaling pathway is regulated by reversible protein …

[HTML][HTML] The human phosphatase interactome: An intricate family portrait

F Sacco, L Perfetto, L Castagnoli, G Cesareni - FEBS letters, 2012 - Elsevier
The concerted activities of kinases and phosphatases modulate the phosphorylation levels
of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are …

The regulation of protein phosphorylation

LN Johnson - Biochemical Society Transactions, 2009 - portlandpress.com
Phosphorylation plays essential roles in nearly every aspect of cell life. Protein kinases
regulate signalling pathways and cellular processes that mediate metabolism, transcription …

Rice qGL3/OsPPKL1 functions with the GSK3/SHAGGY-like kinase OsGSK3 to modulate brassinosteroid signaling

X Gao, JQ Zhang, X Zhang, J Zhou, Z Jiang… - The Plant …, 2019 - academic.oup.com
Brassinosteroids (BRs) are steroid hormones that play essential roles in plant growth and
development. We previously cloned qGL3, a major quantitative trait locus regulating grain …