Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that
also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out …

Pericytes are a heterogeneous population of cells located in the blood vessel wall. They
were first identified in the 19th century by Rouget, however their biological role and potential …

Despite the prevalence of pericytes in the microvasculature of the heart, their role during
ischemia-induced remodeling remains unclear. We used multiple lineage-tracing mouse …

BACKGROUND: Pericytes have been implicated in tissue repair, remodeling, and fibrosis.
Although the mammalian heart contains abundant pericytes, their fate and involvement in …

Bone regeneration following injury is initiated by inflammatory signals and occurs in
association with infiltration by sensory nerve fibers. Together, these events are believed to …

Millions of cardiomyocytes die immediately after myocardial infarction, regardless of whether
the culprit coronary artery undergoes prompt revascularization. Residual ischaemia in the …

In healthy men, several layers of inconspicuously flat cells and extracellular matrix (ECM)
proteins build the wall of the seminiferous tubules. The cells of this wall, peritubular cells, are …

Vascular endothelial cells line the inner surface of the entire cardiovascular system as a
single layer and are involved in an impressive array of functions, ranging from the regulation …

Like most growth factors, neurotrophins are initially synthesized as precursors that are
cleaved to release C-terminal mature forms. The well-characterized mature neurotrophins …

The actions of BDNF (Brain-derived Neurotrophic Factor) in regulating neuronal
development and modulating synaptic activity have been extensively studied and well …