Metastasis to bone is common in lung, kidney, breast and prostate cancers. However,
prostate cancer is unique in that bone is often the only clinically detectable site of …

PURPOSE:: This is part 1 of a 2-part review. Research into the molecular mechanisms
underlying the various aspects of prostate cancer (PCa) requires the use of in vivo and in …

In patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs;
however, pathological fractures frequently occur in PCa patients, and bone resorption is …

HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large
proportion of solid tumor metastases are bone metastases, known to usurp HSC homing …

Background The primary issue arising from prostate cancer (PCa) is its high prevalence to
metastasize to bone, which severely affects the quality of life and survival time of PCa …

In a substantial fraction of prostate cancer (PCa) patients, bone metastasis appears after
years or even decades of latency. Canonical Wnt/β-catenin signaling has been proposed to …

Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway.
Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis …

Purpose: Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging
of tumors. In this study, we show the preferential uptake and retention of two hepatamethine …

Our recent studies have shown that annexin II, expressed on the cell surface of osteoblasts,
plays an important role in the adhesion of hematopoietic stem cells (HSCs) to the endosteal …

CD44, an adhesion molecule that binds to the extracellular matrix, primarily to hyaluronan
(HA), has been implicated in cancer cell migration, invasion, and metastasis. CD44 has also …