Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Brown adipose tissue (BAT) dissipates energy, and promotes cardiometabolic health. Loss
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …

Alcohol is a potent somnogen and one of the most commonly used “over the counter” sleep
aids. In healthy non-alcoholics, acute alcohol decreases sleep latency, consolidates and …

Nucleoside transport in humans is mediated by members of two unrelated protein families,
the SLC28 family of cation-linked concentrative nucleoside transporters (CNTs) and the …

From a structural perspective, the predominant glial cell of the central nervous system, the
astrocyte, is positioned to regulate synaptic transmission and neurovascular coupling: the …

A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …

Equilibrative nucleoside transporters (ENTs) are polytopic integral membrane proteins that
mediate the transport of nucleosides, nucleobases, and therapeutic analogs. The best …

Adenosine is a potent anticonvulsant acting on excitatory synapses through A1 receptors.
Cellular release of ATP, and its subsequent extracellular enzymatic degradation to …

The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …