The vascular blood–brain barrier is a highly regulated interface between the blood and
brain. Its primary function is to protect central neurons while signaling the presence of …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19)
pathogenesis and may predispose to the neurological sequelae associated with long …

Interleukin 6 (IL-6) is a pleiotropic cytokine executing a diverse number of functions, ranging
from its effects on acute phase reactant pathways, B and T lymphocytes, blood brain barrier …

Cognitive dysfunction (CD) is a common yet often clinically subtle manifestation that
considerably impacts the health-related quality of life in patients with systemic lupus …

Neuropsychiatric lupus (NPSLE) is a debilitating manifestation of SLE which occurs in a
majority of SLE patients and has a variety of clinical manifestations. In the central nervous …

Bipolar disorder (BD) often progresses to a more chronic and treatment resistant
(neuroprogressive) course. Identifying which patients are at risk could allow for early …

Objective To study changes in blood brain barrier (BBB) permeability in systemic lupus
erythematosus (SLE) patients, and explore the association between the alterations in BBB …

Cognitive dysfunction (CD) is a neurologic complication of pediatric systemic lupus
erythematosus (SLE) that remains poorly understood and understudied, despite the …

Blood–brain barrier (BBB) dysfunction occurs in many brain diseases, and there is
increasing evidence to suggest that it is an early process in dementia which may be …