Harnessing the potential of optogenetics in biology requires methodologies from different
disciplines ranging from biology, to mechatronics engineering, to control engineering. Light …

Cybergenetics is a novel field of research aiming at remotely pilot cellular processes in real-
time with to leverage the biotechnological potential of synthetic biology. Yet, the control of …

Gene regulatory networks and the dynamic responses they produce offer a wealth of
information about how biological systems process information about their environment …

The design and implementation of synthetic circuits that operate robustly in the cellular
context is fundamental for the advancement of synthetic biology. However, their practical …

Gene expression is inherently dynamic, due to complex regulation and stochastic
biochemical events. However, the effects of these dynamics on cell phenotypes can be …

Gene networks and signaling pathways display complex topologies and, as a result,
complex nonlinear behaviors. Accumulating evidence shows that both static (concentration) …

The cell cycle is the process by which eukaryotic cells replicate. Yeast cells cycle
asynchronously with each cell in the population budding at a different time. Although there …

Living organisms employ endogenous negative feedback loops to maintain homeostasis
despite environmental fluctuations. A pressing open challenge in Synthetic Biology is to …

Cellular systems have evolved numerous mechanisms to adapt to environmental stimuli,
underpinned by dynamic patterns of gene expression. In addition to gene transcription …

Microorganisms have evolved complex strategies for controlling the distribution of available
resources over cellular functions. Biotechnology aims at interfering with these strategies, so …