[HTML][HTML] International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia

GF Watts, SS Gidding, RA Hegele, FJ Raal… - Nature Reviews …, 2023 - nature.com
This contemporary, international, evidence-informed guidance aims to achieve the greatest
good for the greatest number of people with familial hypercholesterolaemia (FH) across …

[HTML][HTML] Recent advances in the management and implementation of care for familial hypercholesterolaemia

NSR Lan, A Bajaj, GF Watts, M Cuchel - Pharmacological research, 2023 - Elsevier
Familial hypercholesterolaemia (FH) is a common autosomal semi-dominant and highly
penetrant disorder of the low-density lipoprotein (LDL) receptor pathway, characterised by …

Low-density lipoprotein cholesterol is predominantly associated with atherosclerotic cardiovascular disease events in patients with evidence of coronary …

MB Mortensen, O Dzaye, HE Bøtker, JM Jensen… - Circulation, 2023 - Am Heart Assoc
Background: Low-density lipoprotein cholesterol (LDL-C) is an important causal risk factor
for atherosclerotic cardiovascular disease (ASCVD). However, a sizable proportion of …

Prevention of cardiovascular disease in young adults: Focus on gender differences. A collaborative review from the EAS Young Fellows

C Antza, A Gallo, C Boutari, A Ershova, KM Gurses… - Atherosclerosis, 2023 - Elsevier
A steady rise in cardiovascular morbidity and mortality has been observed in young adults
within the last decades. This trend corresponds to an increasing prevalence of traditional …

Childhood Screening for Familial Hypercholesterolemia: JACC Review Topic of the Week

SS Gidding - Journal of the American College of Cardiology, 2023 - jacc.org
Screening for familial hypercholesterolemia (FH) in childhood remains controversial.
Existing guidelines offer practitioners conflicting advice despite generally agreeing on the …

[HTML][HTML] Familial hypercholesterolemia and elevated lipoprotein (a): cascade testing and other implications for contextual models of care

WJ Loh, DC Chan, P Mata, GF Watts - Frontiers in Genetics, 2022 - frontiersin.org
Elevated lipoprotein (a)[Lp (a)], a predominantly genetic disorder, is a causal risk factor for
atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valvular disease …

Increased fh-risk-score and diabetes are cardiovascular risk equivalents in heterozygous familial hypercholesterolemia

M Paquette, B Cariou, S Bernard… - … and Vascular Biology, 2024 - Am Heart Assoc
BACKGROUND: Familial hypercholesterolemia (FH) is a genetic condition causing
premature atherosclerotic cardiovascular disease (ASCVD). It is well established that …

Stratification in heterozygous familial hypercholesterolemia: imaging, biomarkers, and genetic testing

P Corral, CA Aguilar Salinas, MG Matta, V Zago… - Current Atherosclerosis …, 2023 - Springer
Abstract Purpose of Review Heterozygous familial hypercholesterolemia (HeFH) is the most
common monogenic autosomal dominant disorder. However, the condition is often …

Visual coronary and aortic calcium scoring on chest computed tomography predict mortality in patients with low-density lipoprotein-cholesterol≥ 190 mg/dL

F Castagna, J Miles, J Arce, E Leiderman… - Circulation …, 2022 - Am Heart Assoc
Background: Current guidelines recommend coronary artery calcium (CAC) scoring for
stratification of atherosclerotic cardiovascular disease risk only in patients with borderline to …

[HTML][HTML] Age-and sex-based heterogeneity in coronary artery plaque presence and burden in familial hypercholesterolemia: a multi-national study

K Nasir, R Mszar, M Cainzos-Achirica… - American Journal of …, 2024 - Elsevier
Objectives Individuals with familial hypercholesterolemia (FH) are at an increased risk for
coronary artery disease (CAD). While prior research has shown variability in coronary artery …