Context Abciximab infusion and uncoated-stent implantation is a complementary treatment
strategy to reduce major adverse cardiac events in patients undergoing angioplasty for ST …

Brain injury after subarachnoid hemorrhage (SAH) is a biphasic event with an acute
ischemic insult at the time of the initial bleed and secondary events such as cerebral …

CD40L (CD154), a member of the tumor necrosis factor superfamily, is a co-stimulatory
molecule that was first discovered on activated T cells. Beyond its fundamental role in …

Acute thrombocytopenia is a recognized complication of treatment with GPIIb/IIIa inhibitors
whose cause is not yet known. We studied 9 patients who developed severe …

ContextThe central role of platelet-rich thrombus in the pathogenesis of acute coronary
syndromes (ACSs) is well-known. Glycoprotein IIb/IIIa (Gp IIb/IIIa) receptor antagonists are …

Introduction Platelets play a key role in arterial thrombosis and antiplatelet therapy is pivotal
in the treatment of cardiovascular disease. Current antiplatelet drugs target different …

Five novel monoclonal antibodies (mAbs; p0p 1-5) were used to characterize the structural
and functional properties and the in vivo expression of the murine GPIb-IX complex (von …

OBJECTIVES We sought to compare the inhibitory effects of the combination of two doses of
aspirin plus clopidogrel with either drug alone on platelet aggregation and activation …

An essential aspect of the treatment of patients with cardiovascular disease is the use of
anticoagulant and antiplatelet agents for the prevention of further ischaemic events and …

Platelet activation by potent, Ca2+-mobilizing agonists results in shedding of microparticles
that are active in coagulation. Here we show that platelets under storage produce …