The clinical efficacy and safety as well as the application range of gene therapy will be
broadened by developing systems capable of finely modulating the expression of …

Over the last 20 years it has been recognized that neurotrophic factors profoundly influence
the development of the nervous system and have the potential to modify disease processes …

We describe post‐transcriptional gene regulation in yeast based on direct RNA–ligand
interaction. Tetracycline‐dependent translational regulation could be imposed via specific …

We delivered the homologous erythropoietin (Epo) cDNA driven from a doxycycline-
regulated promoter via recombinant adeno-associated virus in skeletal muscle of 9 …

Neurosurgical repair in patients with proximal nerve lesions results in unsatisfactory
recovery of function. Gene therapy for neurotrophic factors is a powerful strategy to promote …

We describe the design and detailed characterization of a gas-inducible transgene control
system functional in different mammalian cells, mice and prototype biopharmaceutical …

A spinal root avulsion is the most severe proximal peripheral nerve lesion possible. Avulsion
of ventral root filaments disconnects spinal motoneurons from their target muscles, resulting …

It is feared that the use of gene transfer technology to enhance athletic performance, the
practice that has received the term 'gene doping', may soon become a real threat to the …

Retinal degenerative diseases such as retinal macular degeneration and retinitis
pigmentosa constitute a broad group of diseases that all share one critical feature, the …

This work addresses the problem of efficient control of gene expression in the context of viral
vectors, which still represents a difficult challenge. A number of lentiviral vectors …