Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …

Integral membrane proteins (MPs) are important drug targets across most fields of medicine,
but historically have posed a major challenge for drug discovery due to difficulties in …

Canonical transient receptor potential channels (TRPC) are involved in receptor-operated
and/or store-operated Ca2+ signaling. Inhibition of TRPCs by small molecules was shown to …

The use of styrene–maleic acid (SMA) for the purification of a wide range of membrane
proteins (MPs) from both prokaryotic and eukaryotic sources has begun to make an impact …

Single-particle cryo-electron microscopy (cryo-EM SPA) has recently emerged as an
exceptionally well-suited technique for determining the structure of membrane proteins …

Over the past decade, the structural biology of membrane proteins (MPs) has taken a new
turn thanks to epoch-making technical progress in single-particle electron cryo-microscopy …

Membrane proteins (MPs) need to be extracted from biological membranes and purified in
their native state for most structural and functional in vitro investigations. Amphiphilic …

Integral membrane proteins (IMPs) perform unique and indispensable functions in the cell,
making them attractive targets for fundamental research and drug discovery. Developments …

One of the biggest challenges in membrane protein (MP) research is to secure
physiologically relevant structural and functional information after extracting MPs from their …

Expression of affinity-tagged recombinant proteins for crystallography, protein–protein
interaction, antibody generation, therapeutic applications, etc. mandates the generation of …