Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that takes part in
many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Nicotinamide adenine dinucleotide (NAD) acts as a cofactor in several oxidation-reduction
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …

Background Acute kidney injury (AKI), a common multidisciplinary diagnostic clinical critical
illness, eventually causes end-stage renal disease (ESRD). Although many clinical …

Cardiovascular disease (CVD) is still the leading cause of death worldwide. Despite
successful advances in both pharmacological and lifestyle strategies to fight well …

Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining
attention for the treatment of different cancer types, but also to contrast neurodegenerative …

Summary Bacille Calmette-Guerin (BCG) generates limited long-lasting adaptive memory
responses leading to short-lived protection against adult pulmonary tuberculosis (TB). Here …

Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically
control multiple target genes to modulate diverse biological responses in cells. Among the …

Polycystic ovarian syndrome (PCOS) is the most common multifactor heterogeneous
endocrine and metabolic disease in women of childbearing age. PCOS is a group of clinical …