Antioxidant and anti‐inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental …
H Parhiz, A Roohbakhsh, F Soltani… - Phytotherapy …, 2015 - Wiley Online Library
Inflammation and oxidative stress are two major causes of various life‐threatening diseases.
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species …
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species …
Health-promoting effects of the citrus flavanone hesperidin
C Li, H Schluesener - Critical reviews in food science and nutrition, 2017 - Taylor & Francis
Hesperidin, a member of the flavanone group of flavonoids, can be isolated in large
amounts from the rinds of some citrus species. Considering the wide range of …
amounts from the rinds of some citrus species. Considering the wide range of …
Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling …
Paclitaxel (PTX) is a widely used chemotherapeutic drug particularly effective against lung,
breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity …
breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity …
Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach
Acrylamide (ACR) is a heat-induced carcinogen substance that is found in some foods due
to cooking or other thermal processes. The aim of present study was to assess the probable …
to cooking or other thermal processes. The aim of present study was to assess the probable …
Dysregulation of Nrf2 in hepatocellular carcinoma: role in cancer progression and chemoresistance
The liver executes versatile functions and is the chief organ for metabolism of
toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver …
toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver …
A mechanistic review of the anticancer potential of hesperidin, a natural flavonoid from citrus fruits
Hesperidin, a phytoactive compound, is an abundant and economical dietary bioflavonoid
possessing numerous biological and medicinal benefits. Several studies have strongly …
possessing numerous biological and medicinal benefits. Several studies have strongly …
Targeting Nrf2/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease
Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress …
factor, has been documented to induce a defense mechanism against oxidative stress …
The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats
Paclitaxel (PTX), which is widely used in the treatment of solid tumors, leads to dose
limitation because it causes peripheral neuropathy. This study was conducted to evaluate …
limitation because it causes peripheral neuropathy. This study was conducted to evaluate …
Oxidative stress and liver cancer: etiology and therapeutic targets
Z Wang, Z Li, Y Ye, L Xie, W Li - Oxidative medicine and …, 2016 - Wiley Online Library
Accumulating evidence has indicated that oxidative stress (OS) is associated with the
development of hepatocellular carcinoma (HCC). However, the mechanisms remain largely …
development of hepatocellular carcinoma (HCC). However, the mechanisms remain largely …
The protective effects of hesperidin and curcumin on 5-fluorouracil–induced nephrotoxicity in mice
Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)–treated cancer
patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in …
patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in …