Almost 2 decades after linking LRRK2 to Parkinson's disease, a vibrant research field has
developed around the study of this gene and its protein product. Recent studies have begun …

Parkinson's disease (PD) is defined as a complex disorder with multifactorial pathogenesis,
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic
cause of Parkinson's disease (PD), with growing importance also for Crohn's disease and …

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent
two most common genetic causes of Parkinson's disease (PD). Both genes are important in …

Autophagy, a process of cellular self-digestion, delivers intracellular components including
superfluous and dysfunctional proteins and organelles to the lysosome for degradation and …

In Parkinson's disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia
nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying …

Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the
elderly population and is caused by the loss of dopaminergic neurons. PD has been …

Combining multiple Parkinson's disease (PD) relevant cellular phenotypes might increase
the accuracy of midbrain dopaminergic neuron (mDAN) in vitro models. We differentiated …

Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial
integrity by targeting specific mitochondrial quality control pathways in neurodegenerative …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease.
LRRK2 modulates the autophagy-lysosome pathway (ALP), a clearance process subserving …