Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

The cholinergic system is one of the most important modulatory neurotransmitter systems in
the brain and controls activities that depend on selective attention, which are an essential …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion
channels which are widely distributed in the human brain. Multiple subtypes of these …

Nerve growth factor (NGF) is important for the survival and maintenance of central
cholinergic neurons, a signalling system impaired in Alzheimer's disease. We have treated 3 …

Objective To assess the effect of rivastigmine in patients with mild cognitive impairment
(MCI) on the time to clinical diagnosis of Alzheimer's disease (AD) and the rate of cognitive …

The neuronal nicotinic acetylcholine receptors (nAChRs) in the brain are important for
functional processes, including cognitive and memory functions. The nAChRs acting as …

The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

Background Cholinergic neurotransmitter system dysfunction contributes to cognitive
impairment in Alzheimer's disease and other syndromes. However, the specific cholinergic …

Activation of neuronal nicotinic acetylcholine receptors (nAChRs) has been shown to
maintain cognitive function following aging or the development of dementia. Nicotine and …