Genetics of diabetes mellitus and diabetes complications

JB Cole, JC Florez - Nature reviews nephrology, 2020 - nature.com
Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

The evolving story of incretins (GIP and GLP‐1) in metabolic and cardiovascular disease: a pathophysiological update

MA Nauck, DR Quast, J Wefers… - Diabetes, Obesity and …, 2021 - Wiley Online Library
The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …

Coronavirus infections and type 2 diabetes—shared pathways with therapeutic implications

DJ Drucker - Endocrine reviews, 2020 - academic.oup.com
Abstract Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic, and
viral infections. The severe acute respiratory syndrome (SARS)-CoV-2 (also referred to as …

[HTML][HTML] A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis

PN Newsome, K Buchholtz, K Cusi… - … England Journal of …, 2021 - Mass Medical Soc
Background Nonalcoholic steatohepatitis (NASH) is a common disease that is associated
with increased morbidity and mortality, but treatment options are limited. The efficacy and …

JCS/JHFS 2021 guideline focused update on diagnosis and treatment of acute and chronic heart failure

H Tsutsui, T Ide, H Ito, Y Kihara, K Kinugawa… - Circulation …, 2021 - jstage.jst.go.jp
After the publication of the revised edition, therapeutic drugs described in “Future Treatment”
were approved and important evidence for pharmacologic therapy and nonpharmacologic …

2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The Task Force for diabetes, pre-diabetes …

F Cosentino, PJ Grant, V Aboyans… - European heart …, 2020 - academic.oup.com
Health professionals are encouraged to take the Guidelines fully into account when
exercising their clinical judgment, as well as in the determination and the implementation of …

Trends in antidiabetic drug discovery: FDA approved drugs, new drugs in clinical trials and global sales

AD Dahlén, G Dashi, I Maslov, MM Attwood… - Frontiers in …, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM) continues to be a substantial medical problem due to its
increasing global prevalence and because chronic hyperglycemic states are closely linked …

Metabolically healthy obesity

M Blüher - Endocrine reviews, 2020 - academic.oup.com
Obesity contributes to reduced life expectancy, impaired quality of life, and disabilities,
mainly in those individuals who develop cardiovascular diseases, type 2 diabetes …

[HTML][HTML] Glucagon-like peptide 1 (GLP-1)

TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

[HTML][HTML] 2021 clinical practice guidelines for diabetes mellitus in Korea

KY Hur, MK Moon, JS Park, SK Kim… - Diabetes & …, 2021 - synapse.koreamed.org
Abstract The Committee of Clinical Practice Guidelines of the Korean Diabetes Association
(KDA) updated the previous clinical practice guidelines for Korean adults with diabetes and …