In recent decades, the mechanism underlying bone metabolic disorders based on energy
metabolism has been heavily researched. Bone resorption by osteoclasts plays an important …

Mitochondria, the cell's major energy producers, also act as signaling hubs, interacting with
other organelles both directly and indirectly. Despite having its own circular genome, the …

The brain is one of the most energy-consuming organs in the mammalian body, and
synaptic transmission is one of the major contributors. To meet these energetic …

Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

Dominant optic atrophy is one of the leading causes of childhood blindness. Around 60–
80% of cases are caused by mutations of the gene that encodes optic atrophy protein 1 …

Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory
diseases. Cytochrome c oxidase (C c O), which mediates the rate-limiting step in …

The Mitofusin 2 protein (MFN2), encoded by the MFN2 gene, was first described for its role
in mediating mitochondrial fusion. However, MFN2 is now recognized to play additional …

Mitochondria are extremely pleomorphic organelles. Automatically annotating each one
accurately and precisely in any 2D or volume electron microscopy (EM) image is an …

Mitochondria are known as the powerhouse of eukaryotic cells. Energy production occurs in
specific dynamic membrane invaginations in the inner mitochondrial membrane called …

Mitochondrial structure often determines the function of these highly dynamic,
multifunctional, eukaryotic organelles, which are essential for maintaining cellular health …