In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Back pain is the# 1 cause of years lived with disability worldwide, yet surprisingly little is
known regarding the biology underlying this symptom. We conducted a genome-wide …

Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information‐containing factors, other …

Abstract Purpose of Review Bone remodeling is a diverse field of study with many direct
clinical applications; past studies have implicated epigenetic alterations as key factors of …

Osteoarthritis (OA) is the most common form of arthritis with well recognized multifactorial
nature. While several environmental factors such as older age, obesity and previous joint …

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …

Epigenetics, including DNA methylation, histone modification, and noncoding RNA
regulation, are physiological regulatory changes that affect gene expression without …

Objective The purpose of this review is to describe highlights from original research
publications related to osteoarthritis (OA), epigenetics and genomics with the intention of …

Osteoarthritis (OA) is a common joint disorder with increasing impact in an aging society.
While genetic and transcriptomic analyses have revealed some genes and non-coding loci …