Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Expression and activities of cytochrome P450 enzymes are down-regulated in the liver
during the host response to inflammation or infection, leading to alterations in drug …

In the porcine coronary artery, a cytochrome P450 (CYP) isozyme homologous to CYP
2C8/9 has been identified as an endothelium-derived hyperpolarizing factor (EDHF) …

Blood pressure is regulated by a number of key molecules involving G-protein-coupled
receptors, ion channels and monomeric small G-proteins. The relative contribution of these …

TRPV4 is a broadly expressed Ca2+-permeable cation channel in the vanilloid subfamily of
transient receptor potential channels. TRPV4 gates in response to a large variety of stimuli …

Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize
arachidonic acid to substances which affect arterial tone, it has become increasingly clear …

▪ Abstract CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic
clearance of a wide variety of therapeutic agents, including nonsteroidal antiinflammatories …

Endothelial dysfunction has been implicated as a key factor in the development of a wide
range of cardiovascular diseases, but its definition and mechanisms vary greatly between …

Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …

An endothelium‐derived hyperpolarizing factor (EDHF) that is distinct from nitric oxide (NO)
and prostanoids has been widely hypothesized to hyperpolarize and relax vascular smooth …