Current and emerging therapeutic targets for IBD
MF Neurath - Nature Reviews Gastroenterology & Hepatology, 2017 - nature.com
Various therapeutic advances have led to a paradigm shift in the clinical management of
patients with IBD. The introduction of immunosuppressive (such as azathioprine) and …
patients with IBD. The introduction of immunosuppressive (such as azathioprine) and …
IBD disease-modifying therapies: insights from emerging therapeutics
Inflammatory bowel disease (IBD) pathogenesis is associated with gut mucosal
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …
Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation
D Li, Y Feng, M Tian, J Ji, X Hu, F Chen - Microbiome, 2021 - Springer
Background Ulcerative colitis is a type of chronic inflammatory bowel disease closely
associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley …
associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley …
Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial
Background & Aims Ulcerative colitis (UC) is difficult to treat, and standard therapy does not
always induce remission. Fecal microbiota transplantation (FMT) is an alternative approach …
always induce remission. Fecal microbiota transplantation (FMT) is an alternative approach …
Vedolizumab as induction and maintenance therapy for ulcerative colitis
BG Feagan, P Rutgeerts, BE Sands… - … England Journal of …, 2013 - Mass Medical Soc
Background Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute
effective treatment for ulcerative colitis. Methods We conducted two integrated randomized …
effective treatment for ulcerative colitis. Methods We conducted two integrated randomized …
Bilirubin nanomedicine rescues intestinal barrier destruction and restores mucosal immunity in colitis
Inflammatory bowel disease (IBD) manifests as intestinal barrier destruction, mucosal
immunity dysregulation, and disrupted gut microbiome homeostasis. Conventional anti …
immunity dysregulation, and disrupted gut microbiome homeostasis. Conventional anti …
Reaching the end-game for GWAS: machine learning approaches for the prioritization of complex disease loci
Genome-wide association studies (GWAS) have revealed thousands of genetic loci that
underpin the complex biology of many human traits. However, the strength of GWAS–the …
underpin the complex biology of many human traits. However, the strength of GWAS–the …
TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
K Gerlach, YY Hwang, A Nikolaev, R Atreya… - Nature …, 2014 - nature.com
The molecular checkpoints that drive inflammatory bowel diseases are incompletely
understood. Here we found more T cells expressing the transcription factor PU. 1 and …
understood. Here we found more T cells expressing the transcription factor PU. 1 and …
In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease
R Atreya, H Neumann, C Neufert, MJ Waldner… - Nature medicine, 2014 - nature.com
As antibodies to tumor necrosis factor (TNF) suppress immune responses in Crohn's
disease by binding to membrane-bound TNF (mTNF), we created a fluorescent antibody for …
disease by binding to membrane-bound TNF (mTNF), we created a fluorescent antibody for …
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically
TL Putoczki, S Thiem, A Loving, RA Busuttil, NJ Wilson… - Cancer cell, 2013 - cell.com
Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer" hallmarks" through downstream activation of the gp130/STAT3 …
many of the cancer" hallmarks" through downstream activation of the gp130/STAT3 …