Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

abstract Atopic dermatitis (AD) is the most common chronic skin inflammatory disease, with a
profound impact on patients' quality of life. AD varies considerably in clinical course, age of …

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general
population. Skin barrier dysfunction is the central abnormality leading to AD. The cause of …

Background Atopic dermatitis (AD) is an inflammatory disorder characterized by dominant
type 2 inflammation leading to chronic pruritic skin lesions, allergic comorbidities, and …

The role of the microbiome in the molecular mechanisms underlying allergy has become
highly relevant in recent years. Studies are increasingly suggesting that altered composition …

Atopic dermatitis (AD) is the most common inflammatory skin disease in children. Children
with severe AD have a multidimensional disease burden characterized by skin lesions …

The skin is a physical and immunological barrier to the external environment. Its large
surface area is colonized by diverse communities of microorganisms, including bacteria …

The epidermal inflammation associated with psoriasis drives skin barrier perturbations. The
skin barrier is primarily located in stratum corneum (SC). Its function depends on the SC lipid …

Epidermal barrier dysfunction plays an important role in atopic dermatitis (AD). The difficulty
of objectively assessing AD severity and the introduction of new biologicals into clinical …

Skin barrier dysfunction plays an important role in atopic dermatitis (AD) aetiopathogenesis.
Dupilumab, a drug that inhibits IL‐4 and IL‐13, is an effective treatment for AD but there is …