Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

The aberrant behavior of cancer reflects upregulation of certain oncogenic signaling
pathways that promote proliferation, inhibit apoptosis, and enable the cancer to spread and …

Androgen withdrawal is the only effective therapy for patients with advanced prostate
cancer, but progression to androgen independence ultimately occurs in almost all patients …

Pancreatic cancer is a devastating malignancy, characterized by low responsiveness to
conventional chemotherapies. Gefitinib, an epidermal growth factor receptor-tyrosine kinase …

Stroke is one of the neurological diseases which lead to permanently neuronal damage after
temporary or long-term occlusion of vessels or after heart attack. However, there are few …

Abstract Epidermal Growth Factor Receptor (EGFR) signaling and EGFR mutations play key
roles in cancer pathogenesis, particularly in the development of drug resistance. For the∼ …

Purpose Androgen-independent prostate cancer (AI-PC) is characterized by a higher
invasive potential compared to hormone-responsive prostate cancer. A therapeutic option …

Tumor progression to the invasive phenotype occurs secondary to upregulated signaling
from growth factor receptors that drive key cellular responses like proliferation, migration …

The ability of traditional and newer molecular-based prognostic factors to predict the
outcome of prostate cancer is of considerable interest to urologists, pathologists, and …

The protein tyrosine kinase (PTK) receptors and cytosolic signaling proteins as well as the
protein tyrosine phosphatases (PTPs) have important roles in regulation of growth of the …